Abstract
A study of the antigenic potency of influenza virus inactivated by ultraviolet radiation has been made. Virus so inactivated is still capable of functioning as an immunizing agent when given to mice by the intraperitoneal route. In high concentrations inactivated virus appears to be nearly as effective as active virus but when quantitative comparisons of the immunity induced by different dilutions are made, it is seen that a hundredfold loss in immunizing capacity occurs during inactivation. Virus in suspensions prepared from the lungs of infected mice is inactivated more rapidly than virus in tissue culture medium. A standard for the comparison of vaccines of epidemic influenza virus is proposed.
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Selected References
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- Francis T., Jr TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. Science. 1934 Nov 16;80(2081):457–459. doi: 10.1126/science.80.2081.457-a. [DOI] [PubMed] [Google Scholar]
- Francis T. QUANTITATIVE RELATIONSHIPS BETWEEN THE IMMUNIZING DOSE OF EPIDEMIC INFLUENZA VIRUS AND THE RESULTANT IMMUNITY. J Exp Med. 1939 Jan 31;69(2):283–300. doi: 10.1084/jem.69.2.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hodes H. L., Lavin G. I., Webster L. T. ANTIRABIC IMMUNIZATION WITH CULTURE VIRUS RENDERED AVIRULENT BY ULTRA-VIOLET LIGHT. Science. 1937 Nov 12;86(2237):447–448. doi: 10.1126/science.86.2237.447. [DOI] [PubMed] [Google Scholar]
- Hodes H. L., Webster L. T., Lavin G. I. THE USE OF ULTRAVIOLET LIGHT IN PREPARING A NON-VIRULENT ANTIRABIES VACCINE. J Exp Med. 1940 Sep 30;72(4):437–444. doi: 10.1084/jem.72.4.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rivers T. M., Gates F. L. ULTRA-VIOLET LIGHT AND VACCINE VIRUS : II. THE EFFECT OF MONOCHROMATIC ULTRA-VIOLET LIGHT UPON VACCINE VIRUS. J Exp Med. 1928 Jan 1;47(1):45–49. doi: 10.1084/jem.47.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stock C. C., Francis T. THE INACTIVATION OF THE VIRUS OF EPIDEMIC INFLUENZA BY SOAPS. J Exp Med. 1940 Apr 30;71(5):661–681. doi: 10.1084/jem.71.5.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sturm E., Gates F. L., Murphy J. B. PROPERTIES OF THE CAUSATIVE AGENT OF A CHICKEN TUMOR : II. THE INACTIVATION OF THE TUMOR-PRODUCING AGENT BY MONOCHROMATIC ULTRA-VIOLET LIGHT. J Exp Med. 1932 Feb 29;55(3):441–444. doi: 10.1084/jem.55.3.441. [DOI] [PMC free article] [PubMed] [Google Scholar]