Abstract
A quantitative study of the antigenicity of various vaccines containing influenza A virus has been made in human beings. A complex vaccine prepared from chick embryos inoculated with both influenza A virus and the X strain of canine distemper virus was found to be more effective than other vaccines in stimulating the production of neutralizing antibodies against the former virus. The increased antibody levels which resulted from the administration of this vaccine remained almost unaltered for at least 5 months.
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Selected References
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- Bauer J. H., Pickels E. G. APPARATUS FOR FREEZING AND DRYING VIRUS IN LARGE QUANTITIES UNDER UNIFORM CONDITIONS. J Exp Med. 1940 Jan 1;71(1):83–88. doi: 10.1084/jem.71.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Francis T., Jr, Magill T. P. CULTIVATION OF HUMAN INFLUENZA VIRUS IN AN ARTIFICIAL MEDIUM. Science. 1935 Oct 11;82(2128):353–354. doi: 10.1126/science.82.2128.353. [DOI] [PubMed] [Google Scholar]
- Francis T., Magill T. P. THE ANTIBODY RESPONSE OF HUMAN SUBJECTS VACCINATED WITH THE VIRUS OF HUMAN INFLUENZA. J Exp Med. 1937 Jan 31;65(2):251–259. doi: 10.1084/jem.65.2.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horsfall F. L. A Low Temperature Storage Cabinet for the Preservation of Viruses. J Bacteriol. 1940 Oct;40(4):559–568. doi: 10.1128/jb.40.4.559-568.1940. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horsfall F. L., Hahn R. G., Rickard E. R. FOUR RECENT INFLUENZA EPIDEMICS: AN EXPERIMENTAL STUDY. J Clin Invest. 1940 Mar;19(2):379–392. doi: 10.1172/JCI101140. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horsfall F. L., Jr, Lennette E. H. A COMPLEX VACCINE EFFECTIVE AGAINST DIFFERENT STRAINS OF INFLUENZA VIRUS. Science. 1940 May 24;91(2369):492–494. doi: 10.1126/science.91.2369.492. [DOI] [PubMed] [Google Scholar]
- Horsfall F. L., Lennette E. H. NEUTRALIZATION OF INFLUENZA A VIRUS BY HUMAN SERUM. J Exp Med. 1941 Feb 28;73(3):327–333. doi: 10.1084/jem.73.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horsfall F. L., Lennette E. H. THE SYNERGISM OF HUMAN INFLUENZA AND CANINE DISTEMPER VIRUSES IN FERRETS. J Exp Med. 1940 Aug 31;72(3):247–259. doi: 10.1084/jem.72.3.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horsfall F. L. NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED. J Exp Med. 1939 Jul 31;70(2):209–222. doi: 10.1084/jem.70.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horsfall F. L. Present Status of Knowledge Concerning Influenza. Am J Public Health Nations Health. 1940 Nov;30(11):1302–1310. doi: 10.2105/ajph.30.11.1302. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plummer P. J. Distemper Virus on Chorio-Allantoic Membrane. Can J Comp Med. 1939 Apr;3(4):96–100. [PMC free article] [PubMed] [Google Scholar]
- Stokes J., Chenoweth A. D., Waltz A. D., Gladen R. G., Shaw D. RESULTS OF IMMUNIZATION BY MEANS OF ACTIVE VIRUS OF HUMAN INFLUENZA. J Clin Invest. 1937 Mar;16(2):237–243. doi: 10.1172/JCI100853. [DOI] [PMC free article] [PubMed] [Google Scholar]