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. 1941 Feb 28;73(3):327–333. doi: 10.1084/jem.73.3.327

NEUTRALIZATION OF INFLUENZA A VIRUS BY HUMAN SERUM

Frank L Horsfall Jr 1, Edwin H Lennette 1
PMCID: PMC2135136  PMID: 19871081

Abstract

A linear relationship exists between the quantity of human serum used and the quantity of influenza A virus neutralized. By means of this relationship it is possible to determine the maximum quantity of virus which a given human serum can neutralize. This quantity, the neutralizing capacity, is a fixed value and, unlike the serum dilution end point, is independent of the amount of virus used in the neutralization test.

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Selected References

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  1. Horsfall F. L., Hahn R. G., Rickard E. R. FOUR RECENT INFLUENZA EPIDEMICS: AN EXPERIMENTAL STUDY. J Clin Invest. 1940 Mar;19(2):379–392. doi: 10.1172/JCI101140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Horsfall F. L. NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED. J Exp Med. 1939 Jul 31;70(2):209–222. doi: 10.1084/jem.70.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]

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