Abstract
A fatal infection of irradiated white mice with the Breinl strain of European typhus has been established and passed serially for 22 passages by the intra-abdominal route. Rickettsiae were abundant and easily demonstrable in the moribund or dead mice. The mortality of irradiated mice infected with passage material (peritoneal washings or blood) was nearly 100 per cent as contrasted to no mortality in the control mice given the same dose of x-ray (450 R) and the same volume of fluid intra-abdominally. (The observation period of control mice was arbitrarily limited to 14 days.) After eighteen passages in irradiated mice no increase in virulence for non-irradiated adult mice was detected. After passage in guinea pigs, the rickettsial infection deriving from the mouse passage material was identical with the Breinl strain as judged by fever, cross immunity tests, and brain lesions in sections.
Full Text
The Full Text of this article is available as a PDF (765.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Castaneda M. R. Experimental pneumonia produced by typhus rickettsiae. Am J Pathol. 1939 Jul;15(4):467–476.1. [PMC free article] [PubMed] [Google Scholar]
- Savoor S. R., Velasco R. THE SURVIVAL OF VARIETIES OF TYPHUS VIRUS IN MOUSE PASSAGE, WITH PARTICULAR REFERENCE TO THE VIRUS OF BRILL'S DISEASE. J Exp Med. 1934 Aug 31;60(3):317–322. doi: 10.1084/jem.60.3.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinsser H., Fitzpatrick F., Wei H. A STUDY OF RICKETTSIAE GROWN ON AGAR TISSUE CULTURES. J Exp Med. 1939 Jan 31;69(2):179–190. doi: 10.1084/jem.69.2.179. [DOI] [PMC free article] [PubMed] [Google Scholar]