Abstract
When blood plasma proteins are depleted by bleeding with return of the washed red cells (plasmapheresis) it is possible to bring dogs to a steady state of hypoproteinemia and a uniform plasma protein production on a basal diet limited in protein. Such dogs are clinically normal but have a lowered resistance to infection and certain intoxications. Casein digests given by vein or subcutaneously to such plasma depleted dogs are effective in promoting abundant new plasma protein production. Casein digest L by vein is equivalent to whole liver of like protein equivalence by mouth. The ratio of new plasma protein production to protein intake is 20 to 25 per cent in both instances. Casein digest L by vein gives the same response in plasma protein output as the same digest by mouth. Protein digest X by vein requires addition of tryptophane and cysteine to be effective in plasma protein production. The added cysteine sulfur is more than 95 per cent retained by the dog. The speed of digest injection has no effect on its utilization, within the range tested. Casein digest L given by vein to non-depleted dogs is less well utilized than in dogs depleted of plasma protein.
Full Text
The Full Text of this article is available as a PDF (872.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Elman R. PARENTERAL REPLACEMENT OF PROTEIN WITH THE AMINO-ACIDS OF HYDROLYZED CASEIN. Ann Surg. 1940 Oct;112(4):594–602. doi: 10.1097/00000658-194010000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holman R. L., Mahoney E. B., Whipple G. H. BLOOD PLASMA PROTEIN GIVEN BY VEIN UTILIZED IN BODY METABOLISM : II. A DYNAMIC EQUILIBRIUM BETWEEN PLASMA AND TISSUE PROTEINS. J Exp Med. 1934 Feb 28;59(3):269–282. doi: 10.1084/jem.59.3.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Madden S. C., Finch C. A., Swalbach W. G., Whipple G. H. BLOOD PLASMA PROTEIN PRODUCTION AND UTILIZATION : THE INFLUENCE OF AMINO ACIDS AND OF STERILE ABSCESSES. J Exp Med. 1940 Feb 29;71(3):283–297. doi: 10.1084/jem.71.3.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Madden S. C., George W. E., Waraich G. S., Whipple H. BLOOD PLASMA PROTEIN REGENERATION AS INFLUENCED BY FASTING, INFECTION, AND DIET FACTORS : VARIABLE RESERVE STORES OF PLASMA PROTEIN BUILDING MATERIAL IN THE DOG. J Exp Med. 1938 Apr 30;67(5):675–690. doi: 10.1084/jem.67.5.675. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Madden S. C., Turner A. P., Rowe A. P., Whipple G. H. BLOOD PLASMA PROTEIN PRODUCTION AS INFLUENCED BY VARIOUS DEGREES OF HYPOPROTEINEMIA AND BY AMINO ACIDS. J Exp Med. 1941 Apr 30;73(5):571–580. doi: 10.1084/jem.73.5.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pommerenke W. T., Slavin H. B., Kariher D. H., Whipple G. H. DOG PLASMA PROTEIN GIVEN BY VEIN UTILIZED IN BODY METABOLISM OF DOG : HORSE PLASMA AND DOG HEMOGLOBIN NOT SIMILARLY UTILIZED. J Exp Med. 1935 Jan 31;61(2):283–297. doi: 10.1084/jem.61.2.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wesson L. G. A MODIFICATION OF THE OSBORNEMENDEL SALT MIXTURE CONTAINING ONLY INORGANIC CONSTITUENTS. Science. 1932 Mar 25;75(1943):339–340. doi: 10.1126/science.75.1943.339. [DOI] [PubMed] [Google Scholar]