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. 1941 Sep 30;74(4):359–367. doi: 10.1084/jem.74.4.359

QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN

III. UPTAKE OF COMPLEMENT NITROGEN UNDER VARYING EXPERIMENTAL CONDITIONS

Michael Heidelberger 1, M Rocha e Silva 1, Manfred Mayer 1
PMCID: PMC2135192  PMID: 19871140

Abstract

1. Quantitative data are given on the effect of variations in the time of contact and the proportions of the reactants on the quantity of complement combining component nitrogen (C'1 N) found in active guinea pig serum. 2. C'1 N was the same when determined with precipitates containing excess antibody or excess antigen. 3. Finely divided specific precipitates took up the complement combining component (C'1) from subsequently added guinea pig serum almost as well as specific precipitates formed in the presence of complement.

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Selected References

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  1. Goodner K., Horsfall F. L. THE COMPLEMENT FIXATION REACTION WITH PNEUMOCOCCUS CAPSULAR POLYSACCHARIDE. J Exp Med. 1936 Jul 31;64(2):201–216. doi: 10.1084/jem.64.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Heidelberger M., Kabat E. A. CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : III. A REACTION MECHANISM AND A QUANTITATIVE THEORY. J Exp Med. 1937 May 31;65(6):885–902. doi: 10.1084/jem.65.6.885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heidelberger M., Kendall F. E. A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : III. THE REACTION BETWEEN CRYSTALLINE EGG ALBUMIN AND ITS HOMOLOGOUS ANTIBODY. J Exp Med. 1935 Oct 31;62(5):697–720. doi: 10.1084/jem.62.5.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Heidelberger M., Kendall F. E., Soo Hoo C. M. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : ANTIBODY PRODUCTION IN RABBITS INJECTED WITH AN AZO PROTEIN. J Exp Med. 1933 Jul 31;58(2):137–152. doi: 10.1084/jem.58.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : III. A QUANTITATIVE STUDY AND A THEORY OF THE REACTION MECHANISM. J Exp Med. 1935 Mar 31;61(4):563–591. doi: 10.1084/jem.61.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heidelberger M. QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : I. A METHOD. J Exp Med. 1941 May 31;73(6):681–694. doi: 10.1084/jem.73.6.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heidelberger M., Weil A. J., Treffers H. P. QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : II. THE INTERRELATION OF COMPLEMENT WITH ANTIGEN-ANTIBODY COMPOUNDS AND WITH SENSITIZED RED CELLS. J Exp Med. 1941 May 31;73(6):695–709. doi: 10.1084/jem.73.6.695. [DOI] [PMC free article] [PubMed] [Google Scholar]

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