Abstract
1. Mononuclear phagocytes of immunized animals that had ingested tubercle bacilli in vivo and had subsequently been transplanted and grown in the environment of a normal animal continue to inhibit the multiplication of the microorganism in their cytoplasm in the absence of immune body fluids. 2. Mononuclear phagocytes of immunized animals that had ingested tubercle bacilli in vitro in the presence of immune serum inhibit the multiplication of the microorganism in their cytoplasm to a much greater extent than cells of normal animals that had ingested the bacteria in the same medium and had grown in a similar environment. 3. The presence of immune serum during the in vitro ingestion of tubercle bacilli by mononuclear phagocytes of normal animals does not regularly endow them with increased bacteriostatic properties for the microorganism. Whether or not continued sojourn of normal cells in immune body fluids will confer upon them such properties has not been determined. 4. Mononuclear phagocytes of immunized animals that had ingested tubercle bacilli in vitro in a medium of normal serum and had subsequently grown in an environment devoid of immune body fluids inhibit the multiplication of the microorganism in their cytoplasm to a much greater extent than do normal cells under the same conditions. 5. Active tuberculosis confers on the mononuclear phagocytes themselves increased bacteriostatic properties for the tubercle bacillus which are independent of the immune body fluids or of the organ environment in which they grow.
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Selected References
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- Greene H. S., Saxton J. A. UTERINE ADENOMATA IN THE RABBIT : I. CLINICAL HISTORY, PATHOLOGY AND PRELIMINARY TRANSPLANTATION EXPERIMENTS. J Exp Med. 1938 Apr 30;67(5):691–708. doi: 10.1084/jem.67.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lucké B., Schlumberger H. THE EFFECT OF TEMPERATURE ON THE GROWTH OF FROG CARCINOMA : I. DIRECT MICROSCOPIC OBSERVATIONS ON LIVING INTRAOCULAR TRANSPLANTS. J Exp Med. 1940 Aug 31;72(3):321–330. doi: 10.1084/jem.72.3.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. A CORRELATION BETWEEN THE HISTOLOGICAL CHANGES AND THE FATE OF LIVING TUBERCLE BACILLI IN THE ORGANS OF REINFECTED RABBITS. J Exp Med. 1933 Jan 31;57(2):181–201. doi: 10.1084/jem.57.2.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. ON THE MECHANISM OF IMMUNITY IN TUBERCULOSIS : THE HOST-PARASITE RELATIONSHIP UNDER THE CONDITIONS OF A LOCALIZED AGAR FOCUS OF INFECTION AND THE GENERALIZATION OF THE DISEASE IN NORMAL AND IMMUNIZED RABBITS. J Exp Med. 1936 May 31;63(6):923–946. doi: 10.1084/jem.63.6.923. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. STUDIES ON THE MECHANISM OF IMMUNITY IN TUBERCULOSIS : THE MOBILIZATION OF MONONUCLEAR PHAGOCYTES IN NORMAL AND IMMUNIZED ANIMALS AND THEIR RELATIVE CAPACITIES FOR DIVISION AND PHAGOCYTOSIS. J Exp Med. 1939 Mar 31;69(4):579–599. doi: 10.1084/jem.69.4.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. STUDIES ON THE MECHANISM OF IMMUNITY IN TUBERCULOSIS : THE ROLE OF EXTRACELLULAR FACTORS AND LOCAL IMMUNITY IN THE FIXATION AND INHIBITION OF GROWTH OF TUBERCLE BACILLI. J Exp Med. 1939 Mar 31;69(4):555–578. doi: 10.1084/jem.69.4.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. THE CORRELATION BETWEEN THE HISTOLOGICAL CHANGES AND THE FATE OF LIVING TUBERCLE BACILLI IN THE ORGANS OF TUBERCULOUS RABBITS. J Exp Med. 1932 Jan 1;55(1):31–54. doi: 10.1084/jem.55.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. THE FATE OF BCG AND ASSOCIATED CHANGES IN THE ORGANS OF RABBITS. J Exp Med. 1934 Jul 31;60(2):163–178. doi: 10.1084/jem.60.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moen J. K., Swift H. F. TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : I. TUBERCULIN SENSITIVE TISSUES. J Exp Med. 1936 Aug 31;64(3):339–353. doi: 10.1084/jem.64.3.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seegal D., Seegal B. C. LOCAL ORGAN HYPERSENSITIVENESS : III. FURTHER OBSERVATIONS ON ITS EXPERIMENTAL PRODUCTION IN THE RABBIT EYE. J Exp Med. 1931 Jul 31;54(2):249–263. doi: 10.1084/jem.54.2.249. [DOI] [PMC free article] [PubMed] [Google Scholar]