Abstract
Experimental dietary hepatic injury (diffuse or focal necrosis and cirrhosis in rats, with or without ascites and pleural and pericardial effusion) is determined by the dietary factors instrumental also in the production of fat infiltration of the liver and thus opposed to the lipotropic activity of casein. Accordingly, rats maintained on a diet low in casein with a moderately high or high content of fat and without choline regularly exhibited hepatic injury after between 100 and 150 days. Supplements of l-cystine had an aggravating effect on the production of cirrhosis of the liver, whereas a supplement of choline alone reduced the severity and the incidence of hepatic injury, although not decisively. The combined administration of l-cystine plus choline or of dl-methionine in adequate doses, however, proved to be highly effective in preventing injury to the liver. These conclusions have been corroborated by the use of different modifications of the basal diet. Rats with dietary hepatic injury exhibit, in sequence, changes that vary from diffuse necrosis resembling human acute or subacute yellow atrophy to advanced portal cirrhosis. Diffuse necrotizing nephrosis was a frequent accompaniment of the hepatic injury. Cystine again, proved to be a factor which aggravated this condition.
Full Text
The Full Text of this article is available as a PDF (1.3 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blumberg H., McCollum E. V. THE PREVENTION BY CHOLINE OF LIVER CIRRHOSIS IN RATS ON HIGH FAT, LOW PROTEIN DIETS. Science. 1941 Jun 20;93(2425):598–599. doi: 10.1126/science.93.2425.598. [DOI] [PubMed] [Google Scholar]
- Channon H. J., Manifold M. C., Platt A. P. The action of sulphur-containing amino-acids and proteins on liver fat deposition. Biochem J. 1940 Jun;34(6):866–878. doi: 10.1042/bj0340866. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Connor C. L. Fatty infiltration of the liver and the development of cirrhosis in diabetes and chronic alcoholism. Am J Pathol. 1938 May;14(3):347–364.9. [PMC free article] [PubMed] [Google Scholar]
- Earle D. P., Victor J. CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE. J Exp Med. 1941 Jan 31;73(2):161–172. doi: 10.1084/jem.73.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldblatt H., Kahn J. R., Bayless F., Simon M. A. STUDIES ON EXPERIMENTAL HYPERTENSION : XI. THE EFFECT OF EXCISION OF THE CAROTID SINUSES ON EXPERIMENTAL HYPERTENSION PRODUCED BY RENAL ISCHEMIA. J Exp Med. 1940 Jan 31;71(2):175–185. doi: 10.1084/jem.71.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- György P., Goldblatt H. HEPATIC INJURY ON A NUTRITIONAL BASIS IN RATS. J Exp Med. 1939 Jul 31;70(2):185–192. doi: 10.1084/jem.70.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kinnersley H. W., O'brien J. R., Peters R. A., Reader V. Large scale preparations of vitamin B(1) and vitamin B(4) concentrates. Biochem J. 1933;27(1):225–231. [PMC free article] [PubMed] [Google Scholar]
- Patek A. J., Post J. TREATMENT OF CIRRHOSIS OF THE LIVER BY A NUTRITIOUS DIET AND SUPPLEMENTS RICH IN VITAMIN B COMPLEX. J Clin Invest. 1941 Sep;20(5):481–505. doi: 10.1172/JCI101242. [DOI] [PMC free article] [PubMed] [Google Scholar]