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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1942 May 1;75(5):527–538. doi: 10.1084/jem.75.5.527

ARTERIAL HYPERTENSION IN RATS

II. EFFECTS ON THE KIDNEYS

Henry A Schroeder 1, Charles Neumann 1
PMCID: PMC2135262  PMID: 19871203

Abstract

1. When rats developed cardiac hypertrophy or elevation of blood pressure as a result of one of several methods designed to bring about arterial hypertension, renal vascular disease occurred frequently. 2. When injury to one kidney was followed by cardiac hypertrophy or elevation of blood pressure, vascular lesions were found with considerable regularity in the opposite one, as well as in the one injured. 3. Renal lesions rarely occurred in the absence of cardiac hypertrophy or elevated blood pressure. 4. Renal vascular lesions in rats are occasioned, therefore, by injury to one kidney and are usually associated with, and dependent on, the presence of arterial hypertension.

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Selected References

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  1. Rytand D. A. THE RENAL FACTOR IN ARTERIAL HYPERTENSION WITH COARCTATION OF THE AORTA. J Clin Invest. 1938 Jul;17(4):391–399. doi: 10.1172/JCI100965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Schroeder H. A. ARTERIAL HYPERTENSION IN RATS : I. METHODS. J Exp Med. 1942 May 1;75(5):513–526. doi: 10.1084/jem.75.5.513. [DOI] [PMC free article] [PubMed] [Google Scholar]

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