Abstract
Comparative morphological, histological, and biological studies suggest a close relationship between the meningopneumonitis virus of Francis and Magill and a virus recovered from thiamin-deficient pigeons. Both of these viruses are morphologically identical with typical psittacosis, and it seems probable that they are biologically modified strains of psittacosis. They both differ from typical psittacosis in that they are regularly more pathogenic for the pigeon after intracranial injection, and fail to produce hepatic necrosis after intraperitoneal injection in mice. A virus recently isolated from human cases of atypical pneumonia by Eaton, Beck, and Pearson may also be closely related to these two viruses. A number of psittacosis viruses of pigeon origin showed a similarly increased pathogenicity for pigeons by the intracerebral route, as compared with psittacosis viruses of parrot origin. The viruses of parrot origin, however, commonly produced latent infection in pigeons even when clinical illness was not evidenced. For the isolation of psittacosis of pigeon origin from human sputum the intracranial injection of mice or pigeons may be essential, although it is probable that the intranasal injection of mice would be successful. The intraperitoneal injection of mice may give negative results.
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Selected References
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- Francis T., Magill T. P. AN UNIDENTIFIED VIRUS PRODUCING ACUTE MENINGITIS AND PNEUMONITIS IN EXPERIMENTAL ANIMALS. J Exp Med. 1938 Jul 31;68(2):147–160. doi: 10.1084/jem.68.2.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grace A. W., Suskind F. H. The transmission of lymphogranuloma venereum to the guinea pig. Am J Pathol. 1940 Mar;16(2):169–188.7. [PMC free article] [PubMed] [Google Scholar]
- Rake G., Jones H. P. STUDIES ON LYMPHOGRANULOMA VENEREUM : I. DEVELOPMENT OF THE AGENT IN THE YOLK SAC OF THE CHICKEN EMBRYO. J Exp Med. 1942 Mar 1;75(3):323–338. doi: 10.1084/jem.75.3.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rivers T. M., Berry G. P. PSITTACOSIS : II. EXPERIMENTALLY INDUCED INFECTIONS IN MICE. J Exp Med. 1931 Jun 30;54(1):105–117. doi: 10.1084/jem.54.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]