Abstract
The chick embryo responds to experimental infection with the virus of pseudorabies with a disease pattern simulating the natural infection. Virus lesions of the membrane are followed by infection of all tissues of the central nervous system. Fixed strains produce a hemorrhagic destruction of the central nervous system of the embryo, which is referable to destruction of blood vessel endothelium. Field strains lack the hemorrhagic tendency, but infect the brain when inoculated on the membrane. Neutralization of the virus by specific hyperimmune serum can be demonstrated by inoculation on the membrane. The reaction of the embryo to the virus varies with the age of the embryo. This is reflected both in the membranal lesion and in the subsequent encephalitis.
Full Text
The Full Text of this article is available as a PDF (692.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson K. Pathogenesis of herpes simplex virus infection in chick embryos. Am J Pathol. 1940 Mar;16(2):137–156.7. [PMC free article] [PubMed] [Google Scholar]
- Bang F. EXPERIMENTAL GONOCOCCUS INFECTION OF THE CHICK EMBRYO. J Exp Med. 1941 Sep 30;74(4):387–396. doi: 10.1084/jem.74.4.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Buddingh G. J. A STUDY OF GENERALIZED VACCINIA IN THE CHICK EMBRYO. J Exp Med. 1936 Jan 31;63(2):227–240. doi: 10.1084/jem.63.2.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Buddingh G. J., Polk A. D. EXPERIMENTAL MENINGOCOCCUS INFECTION OF THE CHICK EMBRYO. J Exp Med. 1939 Oct 31;70(5):485–498. doi: 10.1084/jem.70.5.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Buddingh G. J., Womack F. C. OBSERVATIONS ON THE INFECTION OF CHICK EMBRYOS WITH BACTERIUM TULARENSE, BRUCELLA, AND PASTEURELLA PESTIS. J Exp Med. 1941 Aug 31;74(3):213–222. doi: 10.1084/jem.74.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cromartie W. J. Infection of normal and passively immunized chick embryos with corynebacterium diphtheriae. Am J Pathol. 1941 May;17(3):411–420.5. [PMC free article] [PubMed] [Google Scholar]
- Dawson J. R. A study of chick-embryo-adapted rabies virus. Am J Pathol. 1941 Mar;17(2):177–188.7. [PMC free article] [PubMed] [Google Scholar]
- Gallavan M., Goodpasture E. W. Infection of Chick Embryos with H. Pertussis Reproducing Pulmonary Lesions of Whooping Cough. Am J Pathol. 1937 Nov;13(6):927–938.7. [PMC free article] [PubMed] [Google Scholar]
- Goodpasture E. W. Concerning the Pathogenesis of Typhoid Fever. Am J Pathol. 1937 Mar;13(2):175–186.5. [PMC free article] [PubMed] [Google Scholar]
- Hurst E. W. STUDIES ON PSEUDORABIES (INFECTIOUS BULBAR PARALYSIS, MAD ITCH) : II. ROUTES OF INJECTION IN THE RABBIT, WITH REMARKS ON THE RELATION OF THE VIRUS TO OTHER VIRUSES AFFECTING THE NERVOUS SYSTEM. J Exp Med. 1934 May 31;59(6):729–749. doi: 10.1084/jem.59.6.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. AN EXPERIMENTAL STUDY OF "MAD ITCH" WITH ESPECIAL REFERENCE TO ITS RELATIONSHIP TO PSEUDORABIES. J Exp Med. 1931 Jul 31;54(2):233–248. doi: 10.1084/jem.54.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Traub E. CULTIVATION OF PSEUDORABIES VIRUS. J Exp Med. 1933 Nov 30;58(6):663–681. doi: 10.1084/jem.58.6.663. [DOI] [PMC free article] [PubMed] [Google Scholar]