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. 1943 Sep 1;78(3):151–159. doi: 10.1084/jem.78.3.151

THE ELIMINATION OF ADMINISTERED ZINC IN PANCREATIC JUICE, DUODENAL JUICE, AND BILE OF THE DOG AS MEASURED BY ITS RADIOACTIVE ISOTOPE (Zn65)

M Laurence Montgomery 1, G E Sheline 1, I L Chaikoff 1
PMCID: PMC2135328  PMID: 19871318

Abstract

The excretion of intravenously injected labeled zinc into pancreatic juice, duodenal juice, and bile of the dog was investigated. The use of the radioactive isotope permitted the injection of minute amounts of zinc, amounts that were negligible when compared with the total amount of zinc already present in the animal. 1. A large proportion of the injected Zn65 was eliminated by way of the external secretion of the pancreas. As much as 11 per cent was excreted in the pancreatic juice in 14 days. 2. Very little of the administered radiozinc appeared in the bile. The maximum excretion observed for this pathway was 0.4 per cent in 8 days. 3. Radiozinc was also found in large amounts in the juice obtained from an isolated loop of the duodenum.

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Selected References

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  1. Cohn E. J., Ferry J. D., Livingood J. J., Blanchard M. H. STUDIES IN THE PHYSICAL CHEMISTRY OF INSULIN. Science. 1939 Aug 25;90(2330):183–185. doi: 10.1126/science.90.2330.183-a. [DOI] [PubMed] [Google Scholar]
  2. Elman R., McCaughan J. M. ON THE COLLECTION OF THE ENTIRE EXTERNAL SECRETION OF THE PANCREAS UNDER STERILE CONDITIONS AND THE FATAL EFFECT OF TOTAL LOSS OF PANCREATIC JUICE. J Exp Med. 1927 Feb 28;45(3):561–570. doi: 10.1084/jem.45.3.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Rous P., McMaster P. D. A METHOD FOR THE PERMANENT STERILE DRAINAGE OF INTRAABDOMINAL DUCTS, AS APPLIED TO THE COMMON DUCT. J Exp Med. 1923 Jan 1;37(1):11–19. doi: 10.1084/jem.37.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Scott D. A. Crystalline insulin. Biochem J. 1934;28(4):1592–1602.1. doi: 10.1042/bj0281592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Scott D. A., Fisher A. M. Crystalline insulin. Biochem J. 1935 May;29(5):1048–1054. doi: 10.1042/bj0291048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Scott D. A., Fisher A. M. THE INSULIN AND THE ZINC CONTENT OF NORMAL AND DIABETIC PANCREAS. J Clin Invest. 1938 Nov;17(6):725–728. doi: 10.1172/JCI101000. [DOI] [PMC free article] [PubMed] [Google Scholar]

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