Abstract
Persistent hypertension has been produced in the goat and sheep by constriction of the main renal arteries. The presence or absence of accompanying uremia depends upon the degree of constriction of the renal arteries. In both sheep and goat, constriction of one main renal artery also caused elevation of the blood pressure which tended to persist longer than in the dog. Excision of the one kidney with main renal artery constricted resulted in a prompt (24 hours) return of the blood pressure to normal. In the animals with hypertension of long duration but without renal excretory insufficiency, (the "benign" phase) no significant arterio- or arteriolosclerosis developed as a result of the hypertension alone. In the animals that had both hypertension and renal excretory insufficiency, (the "malignant" phase) the typical terminal arteriolar lesions developed in many organs. These lesions consisted of necrosis and fibrinoid degeneration of arterioles and necrotizing arteriolitis which should not be confused with arteriolosclerosis. The same humoral mechanism which is responsible for experimental renal hypertension in the dog and other animals also obtains in the pathogenesis of experimental renal hypertension in the sheep and goat.
Full Text
The Full Text of this article is available as a PDF (468.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Drury D. R. THE PRODUCTION BY A NEW METHOD OF RENAL INSUFFICIENCY AND HYPERTENSION IN THE RABBIT. J Exp Med. 1938 Oct 31;68(5):693–701. doi: 10.1084/jem.68.5.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fasciolo J. C., Houssay B. A., Taquini A. C. The blood-pressure raising secretion of the ischaemic kidney. J Physiol. 1938 Dec 14;94(3):281–293. doi: 10.1113/jphysiol.1938.sp003680. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldblatt H., Lynch J., Hanzal R. F., Summerville W. W. STUDIES ON EXPERIMENTAL HYPERTENSION : I. THE PRODUCTION OF PERSISTENT ELEVATION OF SYSTOLIC BLOOD PRESSURE BY MEANS OF RENAL ISCHEMIA. J Exp Med. 1934 Feb 28;59(3):347–379. doi: 10.1084/jem.59.3.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldblatt H. STUDIES ON EXPERIMENTAL HYPERTENSION : III. THE PRODUCTION OF PERSISTENT HYPERTENSION IN MONKEYS (MACAQUE) BY RENAL ISCHEMIA. J Exp Med. 1937 Apr 30;65(5):671–675. doi: 10.1084/jem.65.5.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldblatt H. STUDIES ON EXPERIMENTAL HYPERTENSION : VII. THE PRODUCTION OF THE MALIGNANT PHASE OF HYPERTENSION. J Exp Med. 1938 Apr 30;67(5):809–826. doi: 10.1084/jem.67.5.809. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis H. A., Goldblatt H. Studies on Experimental Hypertension: XVIII. Experimental Observations on the Humoral Mechanism of Hypertension. Bull N Y Acad Med. 1942 Jul;18(7):459–487. [PMC free article] [PubMed] [Google Scholar]
- Page I. H. A METHOD FOR PRODUCING PERSISTENT HYPERTENSION BY CELLOPHANE. Science. 1939 Mar 24;89(2308):273–274. doi: 10.1126/science.89.2308.273. [DOI] [PubMed] [Google Scholar]