Abstract
By preliminary preparation of the skin in ways that render it hyperplastic the presence of infective virus can be demonstrated in extracts of domestic rabbit papillomas which yield no growths when inoculated by the ordinary methods and which for this reason have been supposed to contain no virus. The amount of virus recovered by the method outlined in the present work, however, is small when compared with the yield obtained in most instances from comparable cottontail rabbit papillomas. The yield is greatly influenced not only by the virus strain used to produce the growths but by the individual rabbit host. Although virus has been obtained from papillomas produced in domestic rabbits by all of the virus strains tested, a total of 21 thus far, only about one-fourth of these strains are readily to be procured again from the growths they cause and the others are demonstrable only in hosts in which the conditions are favorable for reasons unknown. An experimental comparison of the capacity of suspensions of papilloma tissue from domestic and cottontail rabbits to elicit specific antibodies has shown that the titers attained are approximately proportional to the amount of infective virus demonstrable in the suspensions. The findings as a whole indicate that far less virus exists in infective or antigenic form in the papillomas of domestic rabbits than in those of cottontail rabbits.
Full Text
The Full Text of this article is available as a PDF (761.7 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beard J. W., Wyckoff R. W. THE ISOLATION OF A HOMOGENEOUS HEAVY PROTEIN FROM VIRUS-INDUCED RABBIT PAPILLOMAS. Science. 1937 Feb 19;85(2199):201–202. doi: 10.1126/science.85.2199.201. [DOI] [PubMed] [Google Scholar]
- Bernheim F., Bernheim M. L., Taylor A. R., Beard D., Sharp D. G., Beard J. W. A FACTOR IN DOMESTIC RABBIT PAPILLOMA TISSUE HYDROLYZING THE PAPILLOMA VIRUS PROTEIN. Science. 1942 Feb 27;95(2461):230–231. doi: 10.1126/science.95.2461.230. [DOI] [PubMed] [Google Scholar]
- Friedewald W. F. CELL STATE AS AFFECTING SUSCEPTIBILITY TO A VIRUS : ENHANCED EFFECTIVENESS OF THE RABBIT PAPILLOMA VIRUS ON HYPERPLASTIC EPIDERMIS. J Exp Med. 1942 Jan 31;75(2):197–220. doi: 10.1084/jem.75.2.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Friedewald W. F. IDENTITY OF "INHIBITOR" AND ANTIBODY IN EXTRACTS OF VIRUS-INDUCED RABBIT PAPILLOMAS. J Exp Med. 1940 Jul 31;72(2):175–200. doi: 10.1084/jem.72.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Friedewald W. F., Kidd J. G. UNION IN VITRO OF THE PAPILLOMA VIRUS AND ITS ANTIBODY. J Exp Med. 1940 Oct 31;72(5):531–558. doi: 10.1084/jem.72.5.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kidd J. G., Beard J. W., Rous P. SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS : II. TESTS OF THE BLOOD OF ANIMALS CARRYING VARIOUS EPITHELIAL TUMORS. J Exp Med. 1936 Jun 30;64(1):79–96. doi: 10.1084/jem.64.1.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kidd J. G. IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : III. ANTIGENICITY AND PATHOGENICITY OF EXTRACTS OF THE GROWTHS OF WILD AND DOMESTIC SPECIES: GENERAL DISCUSSION. J Exp Med. 1938 Oct 31;68(5):737–759. doi: 10.1084/jem.68.5.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kidd J. G., Rous P. A TRANSPLANTABLE RABBIT CARCINOMA ORIGINATING IN A VIRUS-INDUCED PAPILLOMA AND CONTAINING THE VIRUS IN MASKED OR ALTERED FORM. J Exp Med. 1940 May 31;71(6):813–838. doi: 10.1084/jem.71.6.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kidd J. G. THE DETECTION OF A "MASKED" VIRUS (THE SHOPE PAPILLOMA VIRUS) BY MEANS OF IMMUNIZATION : RESULTS OF IMMUNIZATION WITH MIXTURES CONTAINING VIRUS AND ANTIBODY. J Exp Med. 1941 Sep 30;74(4):321–344. doi: 10.1084/jem.74.4.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kidd J. G. THE MASKING EFFECT OF EXTRAVASATED ANTIBODY ON THE RABBIT PAPILLOMA VIRUS (SHOPE). J Exp Med. 1939 Nov 30;70(6):583–604. doi: 10.1084/jem.70.6.583. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kidd J. G. THE MASKING EFFECT OF EXTRAVASATED ANTIBODY ON THE RABBIT PAPILLOMA VIRUS (SHOPE). J Exp Med. 1939 Nov 30;70(6):583–604. doi: 10.1084/jem.70.6.583. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E., Hurst E. W. INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY. J Exp Med. 1933 Oct 31;58(5):607–624. doi: 10.1084/jem.58.5.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E., Hurst E. W. INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY. J Exp Med. 1933 Oct 31;58(5):607–624. doi: 10.1084/jem.58.5.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. IMMUNIZATION OF RABBITS TO INFECTIOUS PAPILLOMATOSIS. J Exp Med. 1937 Jan 31;65(2):219–231. doi: 10.1084/jem.65.2.219. [DOI] [PMC free article] [PubMed] [Google Scholar]