Abstract
The presence of fat in the diet accelerates the production of hepatic tumors by p-dimethylaminoazobenzene (butter yellow), and when its quantity is very small, few are produced. Butter yellow with diets consisting in large part of rice, or with other diets with low protein content, causes nodular cirrhosis, but, rice substituted for sugar in a diet containing protein, fat, and butter yellow with adequate vitamins accelerates the production of tumors though the added rice is insufficient to induce nodular cirrhosis. Rice favors the production of hepatic tumors by agencies that are not yet explained. Butter yellow produces hepatic tumors in the absence of cirrhosis, but with diets that produce cirrhosis, the frequency of tumors and of their precursors, cystic ducts and cholangiofibrosis, increases with the severity of cirrhosis.
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Selected References
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- Blumberg H., McCollum E. V. THE PREVENTION BY CHOLINE OF LIVER CIRRHOSIS IN RATS ON HIGH FAT, LOW PROTEIN DIETS. Science. 1941 Jun 20;93(2425):598–599. doi: 10.1126/science.93.2425.598. [DOI] [PubMed] [Google Scholar]
- György P., Goldblatt H. OBSERVATIONS ON THE CONDITIONS OF DIETARY HEPATIC INJURY (NECROSIS, CIRRHOSIS) IN RATS. J Exp Med. 1942 Apr 1;75(4):355–368. doi: 10.1084/jem.75.4.355. [DOI] [PMC free article] [PubMed] [Google Scholar]
- György P., Tomarelli R., Ostergard R. P., Brown J. B. UNSATURATED FATTY ACIDS IN THE DIETARY DESTRUCTION OF N,N-DIMETHYLAMINOAZOBENZENE (BUTTER YELLOW) AND IN THE PRODUCTION OF ANEMIA IN RATS. J Exp Med. 1942 Nov 1;76(5):413–420. doi: 10.1084/jem.76.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kensler C. J., Sugiura K., Young N. F., Halter C. R., Rhoads C. P. PARTIAL PROTECTION OF RATS BY RIBOFLAVIN WITH CASEIN AGAINST LIVER CANCER CAUSED BY DIMETHYL-AMINOAZOBENZENE. Science. 1941 Mar 28;93(2413):308–310. doi: 10.1126/science.93.2413.308. [DOI] [PubMed] [Google Scholar]
- Opie E. L. THE PATHOGENESIS OF TUMORS OF THE LIVER PRODUCED BY BUTTER YELLOW. J Exp Med. 1944 Sep 1;80(3):231–246. doi: 10.1084/jem.80.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]