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. 1946 May 31;83(6):505–518.

SULFONAMIDE CHEMOTHERAPY OF COMBINED INFECTION WITH INFLUENZA VIRUS AND BACTERIA

Carl G Harford 1, Mary Ruth Smith 1, W Barry Wood Jr 1
PMCID: PMC2135587  PMID: 19871547

Abstract

1. Sulfonamide chemotherapy controls the bacterial component of combined infection with influenza virus and pneumococci in rats. 2. Reinstillation of fluid (broth, physiological salt solution) into the respiratory passages of mice several days after sublethal viral infection converts the viral infection into a lethal one. 3. Sulfonamide chemotherapy controls the bacterial component of combined bacterial and viral infection of mice, produced by intrabronchial inoculation of mixtures of bacteria and sublethal or lethal doses of virus. 4. Bacterial pneumonia may be superimposed upon sublethal viral infection in mice by inhalation of fine droplets of bacterial suspension several days after inoculation of virus. Normal mice inhaling fine droplets of bacterial suspension fail to develop obvious disease. 5. Sulfonamide chemotheiapy controls bacterial pneumonia superimposed on sublethal viral infection by inhalation of fine droplets of bacterial culture. 6. The secondary bacterial penumonia does not convert the sublethal viral infection into a lethal one. 7. If another pandemic of influenza occurs, it is probable that sulfonamide chemotherapy will be valuable in the treatment of secondary bacterial pneumonia and will be effective in lowering the case fatality rate if the viral component of the infection is not severe enough by itself to cause death.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adamson J. D., Flett R. O. The Inefficacy of Sulfapyridine in Influenza. Can Med Assoc J. 1942 Feb;46(2):121–123. [PMC free article] [PubMed] [Google Scholar]
  2. Bang F. B. SYNERGISTIC ACTION OF HEMOPHILUS INFLUENZAE SUIS AND THE SWINE INFLUENZA VIRUS ON THE CHICK EMBRYO. II. J Exp Med. 1943 Jul 1;78(1):9–16. doi: 10.1084/jem.78.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bang F. B. SYNERGISTIC ACTION OF HEMOPHILUS INFLUENZAE SUIS AND THE SWINE INFLUENZA VIRUS ON THE CHICK EMBRYO. J Exp Med. 1943 Jan 1;77(1):7–20. doi: 10.1084/jem.77.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Branch A., Stillman E. G. PATHOLOGY OF EXPERIMENTAL PNEUMOCOCCUS PNEUMONIA IN MICE. J Exp Med. 1924 Nov 30;40(6):743–752. doi: 10.1084/jem.40.6.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clinical Memoranda. Br Med J. 1938 Apr 23;1(4033):895–896. [PMC free article] [PubMed] [Google Scholar]
  6. Finland M., Barnes M. W., Samper B. A. INFLUENZA VIRUS ISOLATIONS AND SEROLOGICAL STUDIES MADE IN BOSTON DURING THE WINTER OF 1943-1944. J Clin Invest. 1945 Mar;24(2):192–208. doi: 10.1172/JCI101597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Francis T. Epidemic Influenza. Bull N Y Acad Med. 1941 Apr;17(4):268–279. [PMC free article] [PubMed] [Google Scholar]
  8. Francis T., Stuart-Harris C. H. STUDIES ON THE NASAL HISTOLOGY OF EPIDEMIC INFLUENZA VIRUS INFECTION IN THE FERRET : I. THE DEVELOPMENT AND REPAIR OF THE NASAL LESION. J Exp Med. 1938 Oct 31;68(6):789–802. doi: 10.1084/jem.68.6.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hamburger M., Robertson O. H. STUDIES ON THE PATHOGENESIS OF EXPERIMENTAL PNEUMOCOCCUS PNEUMONIA IN THE DOG : I. SECONDARY PULMONARY LESIONS. RELATIONSHIP OF BRONCHIAL OBSTRUCTION AND DISTRIBUTION OF PNEUMOCOCCI TO THEIR INCEPTION. J Exp Med. 1940 Aug 31;72(3):261–274. doi: 10.1084/jem.72.3.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jourdonais L., Nungester W. J. INTRATRACHEAL INOCULATIONS IN THE RAT. Science. 1935 Jan 18;81(2090):74–74. doi: 10.1126/science.81.2090.74. [DOI] [PubMed] [Google Scholar]
  11. Lewis P. A., Shope R. E. SWINE INFLUENZA : II. A HEMOPHILIC BACILLUS FROM THE RESPIRATORY TRACT OF INFECTED SWINE. J Exp Med. 1931 Jul 31;54(3):361–371. doi: 10.1084/jem.54.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Macleod C. M. THE INHIBITION OF THE BACTERIOSTATIC ACTION OF SULFONAMIDE DRUGS BY SUBSTANCES OF ANIMAL AND BACTERIAL ORIGIN. J Exp Med. 1940 Aug 31;72(3):217–232. doi: 10.1084/jem.72.3.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. PERSONNEL OF NAVAL LABORATORY RESEARCH UNIT NO. 1 ATTEMPTS TO PROTECT AGAINST INFLUENZA VIRUS WITH VARIOUS SULFONAMIDES, ACRIDINES AND ANTIBIOTICS. Science. 1943 Oct 15;98(2546):348–349. doi: 10.1126/science.98.2546.348. [DOI] [PubMed] [Google Scholar]
  14. Robertson O. H., Bigg E., Puck T. T., Miller B. F., Technical Assistance of Elizabeth A. Appell THE BACTERICIDAL ACTION OF PROPYLENE GLYCOL VAPOR ON MICROORGANISMS SUSPENDED IN AIR. I. J Exp Med. 1942 Jun 1;75(6):593–610. doi: 10.1084/jem.75.6.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Robertson O. H., Hamburger M. STUDIES ON THE PATHOGENESIS OF EXPERIMENTAL PNEUMOCOCCUS PNEUMONIA IN THE DOG : II. SECONDARY PULMONARY LESIONS. THEIR PRODUCTION BY INTRATRACHEAL AND INTRABRONCHIAL INJECTION OF FLUID PNEUMONIC EXUDATE. J Exp Med. 1940 Aug 31;72(3):275–288. doi: 10.1084/jem.72.3.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Robertson O. H., Puck T. T., Lemon H. F., Loosli C. G. THE LETHAL EFFECT OF TRIETHYLENE GLYCOL VAPOR ON AIR-BORNE BACTERIA AND INFLUENZA VIRUS. Science. 1943 Feb 5;97(2510):142–144. doi: 10.1126/science.97.2510.142. [DOI] [PubMed] [Google Scholar]
  17. Shope R. E., Francis T. THE SUSCEPTIBILITY OF SWINE TO THE VIRUS OF HUMAN INFLUENZA. J Exp Med. 1936 Oct 31;64(5):791–801. doi: 10.1084/jem.64.5.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Shope R. E. SWINE INFLUENZA : III. FILTRATION EXPERIMENTS AND ETIOLOGY. J Exp Med. 1931 Jul 31;54(3):373–385. doi: 10.1084/jem.54.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Taylor R. M. EXPERIMENTAL INFECTION WITH INFLUENZA A VIRUS IN MICE : THE INCREASE IN INTRAPULMONARY VIRUS AFTER INOCULATION AND THE INFLUENCE OF VARIOUS FACTORS THEREON. J Exp Med. 1941 Jan 1;73(1):43–55. doi: 10.1084/jem.73.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wells W. F. AN APPARATUS FOR THE STUDY OF EXPERIMENTAL AIR-BORNE DISEASE. Science. 1940 Feb 16;91(2355):172–174. doi: 10.1126/science.91.2355.172-a. [DOI] [PubMed] [Google Scholar]
  21. Wood W. B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : I. THE ACTION OF TYPE SPECIFIC ANTIBODY UPON THE PULMONARY LESION OF EXPERIMENTAL PNEUMONIA. J Exp Med. 1941 Jan 31;73(2):201–222. doi: 10.1084/jem.73.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]

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