Abstract
Six groups of rats on different diets were exposed to the inhalation of carbon tetrachloride (about 300 p. p. m.) for 150 days. Food intake and changes in weight were followed throughout the experiment. Animals fed a diet low in protein showed greater susceptibility than rats on a diet high in protein. Methionine was a good substitute for protein (casein) in the diet. Increase in fat intake with correspondingly lower carbohydrate intake exerted a harmful effect, especially evident in combination with a low protein diet. In this change of the fat: carbohydrate ratio, whether the increased fat or the lowered carbohydrate is the specific factor must remain unanswered at the present time. Necrotizing nephrosis was the presenting sign of the intoxication caused by carbon tetrachloride, in addition to hepatic changes, such as hydropic degeneration, necrosis, and cirrhosis. Dietary factors (methionine and methionine-containing protein, as well as low fat intake) more consistently prevented renal injury than cirrhosis of the liver. Under identical dietary conditions, especially with higher fat intake, male rats appeared to evince greater susceptibility to carbon tetrachloride than female rats. The significance of this observation and its wider applicability has been discussed.
Full Text
The Full Text of this article is available as a PDF (733.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Davis N. C. The Influence of Diet upon the Liver Injury produced by Carbon Tetrachloride. J Med Res. 1924 Sep;44(5):601–614.3. [PMC free article] [PubMed] [Google Scholar]
- Eschenbrenner A. B., Miller E. SEX DIFFERENCES IN KIDNEY MORPHOLOGY AND CHLOROFORM NECROSIS. Science. 1945 Sep 21;102(2647):302–303. doi: 10.1126/science.102.2647.302. [DOI] [PubMed] [Google Scholar]
- Goldschmidt S., Vars H. M., Ravdin I. S. THE INFLUENCE OF THE FOODSTUFFS UPON THE SUSCEPTIBILITY OF THE LIVER TO INJURY BY CHLOROFORM, AND THE PROBABLE MECHANISM OF THEIR ACTION. J Clin Invest. 1939 May;18(3):277–289. doi: 10.1172/JCI101044. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller L. L., Whipple G. H. LIVER INJURY, LIVER PROTECTION, AND SULFUR METABOLISM : METHIONINE PROTECTS AGAINST CHLOROFORM LIVER INJURY EVEN WHEN GIVEN AFTER ANESTHESIA. J Exp Med. 1942 Nov 1;76(5):421–435. doi: 10.1084/jem.76.5.421. [DOI] [PMC free article] [PubMed] [Google Scholar]