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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1947 Mar 31;85(4):405–416. doi: 10.1084/jem.85.4.405

EPIDEMIC DIARRHEAL DISEASE OF SUCKLING MICE

I. MANIFESTATIONS, EPIDEMIOLOGY, AND ATTEMPTS TO TRANSMIT THE DISEASE

F Sargent Cheever 1, J Howard Mueller 1
PMCID: PMC2135614  PMID: 19871625

Abstract

1. The disease was almost certainly infectious. 2. Its eradication offered much greater practical difficulties than are presented by certain other infections of mice. 3. A definite tendency toward greater susceptibility in first litters as contrasted with subsequent ones was noted. 4. Advantage could be taken of this increasing resistance to keep the infected colony in efficient production, but accidental loss of the stock prevented the continuation of the plan for a time sufficient to exclude possible failure due to seasonal variation. 5. Multiple etiologies may well have existed even within this circumscribed outbreak. 6. Experimental investigation of the condition offers extraordinary difficulties but its thorough understanding promises to bring new light to basic problems of disease.

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Selected References

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  1. Syverton J. T., Olitsky P. K. BACTERIOLOGICAL STUDIES ON AN EPIZOOTIC OF INTESTINAL DISEASE IN SUCKLING AND NEWLY WEANED MICE. J Exp Med. 1934 Aug 31;60(3):385–394. doi: 10.1084/jem.60.3.385. [DOI] [PMC free article] [PubMed] [Google Scholar]

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