Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1946 Sep 30;84(4):377–386. doi: 10.1084/jem.84.4.377

STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA

III. FACTORS INFLUENCING THE PHAGOCYTOSIS OF PNEUMOCOCCI IN THE LUNG DURING SULFONAMIDE THERAPY

W Barry Wood Jr 1, Charlotte McLeod 1, Edwin N Irons 1
PMCID: PMC2135633  PMID: 19871576

Abstract

The phagocytosis which occurs in the lungs of rats receiving sulfonamide is due neither to an opsonizing action of the sulfonamides nor to type-specific antibody. The evidence presented indicates that the destruction of the pneumococci is brought about by a phagocytic mechanism independent of both opsonization and capsular injury.

Full Text

The Full Text of this article is available as a PDF (654.9 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Finland M., Sutliff W. D. IMMUNITY REACTIONS OF HUMAN SUBJECTS TO STRAINS OF PNEUMOCOCCI OTHER THAN TYPES I, II AND III. J Exp Med. 1933 Jan 1;57(1):95–109. doi: 10.1084/jem.57.1.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Heidelberger M., Anderson D. G. THE IMMUNE RESPONSE OF HUMAN BEINGS TO BRIEF INFECTIONS WITH PNEUMOCOCCUS. J Clin Invest. 1944 Sep;23(5):607–612. doi: 10.1172/JCI101531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heidelberger M., Kendall F. E. QUANTITATIVE STUDIES ON ANTIBODY PURIFICATION : I. THE DISSOCIATION OF PRECIPITATES FORMED BY PNEUMOCOCCUS SPECIFIC POLYSACCHARIDES AND HOMOLOGOUS ANTIBODIES. J Exp Med. 1936 Jul 31;64(2):161–172. doi: 10.1084/jem.64.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kelley W. H. THE ANTIPNEUMOCOCCUS PROPERTIES OF NORMAL SWINE SERUM. J Exp Med. 1932 May 31;55(6):877–888. doi: 10.1084/jem.55.6.877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lord F. T., Persons E. L. CERTAIN ASPECTS OF MOUSE PROTECTION TESTS FOR ANTIBODY IN PNEUMOCOCCUS PNEUMONIA. J Exp Med. 1931 Jan 31;53(2):151–158. doi: 10.1084/jem.53.2.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Nye R. N., Harris A. H. Viable Pneumococci and Pneumococcic Specific Soluble Substance in the Lungs from Cases of Lobar Pneumonia. Am J Pathol. 1937 Sep;13(5):749–767. [PMC free article] [PubMed] [Google Scholar]
  7. Robertson O. H., Graeser J. B., Coggeshall L. T., Harrison M. A. THE RELATION OF CIRCULATING ANTIPNEUMOCOCCAL IMMUNE SUBSTANCES TO THE COURSE OF LOBAR PNEUMONIA I. NATURAL IMMUNE SUBSTANCES. J Clin Invest. 1934 Jul;13(4):621–631. doi: 10.1172/JCI100610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Robertson O. H., Graeser J. B., Coggeshall L. T., Harrison M. A. THE RELATION OF CIRCULATING ANTIPNEUMOCOCCAL IMMUNE SUBSTANCES TO THE COURSE OF LOBAR PNEUMONIA II. ACQUIRED IMMUNE SUBSTANCES. J Clin Invest. 1934 Jul;13(4):633–647. doi: 10.1172/JCI100611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Robertson O. H., Sia R. H. STUDIES ON PNEUMOCOCCUS GROWTH INHIBITION : VII. THE RELATION OF OPSONINS TO NATURAL RESISTANCE AGAINST PNEUMOCOCCUS INFECTION. J Exp Med. 1927 Jul 31;46(2):239–262. doi: 10.1084/jem.46.2.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sia R. H. STUDIES ON PNEUMOCOCCUS GROWTH INHIBITION : VI. THE SPECIFIC EFFECT OF PNEUMOCOCCUS SOLUBLE SUBSTANCE ON THE GROWTH OF PNEUMOCOCCI IN NORMAL SERUM-LEUCOCYTE MIXTURES. J Exp Med. 1926 Apr 30;43(5):633–645. doi: 10.1084/jem.43.5.633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tillett W. S., Cambier M. J., Dunn H. SPECIFIC ANTIPNEUMOCOCCAL IMMUNITY IN RELATION TO THE CHEMOTHERAPY OF PNEUMONIA. J Clin Invest. 1942 Sep;21(5):511–523. doi: 10.1172/JCI101328. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ward H. K., Enders J. F. AN ANALYSIS OF THE OPSONIC AND TROPIC ACTION OF NORMAL AND IMMUNE SERA BASED ON EXPERIMENTS WITH THE PNEUMOCOCCUS. J Exp Med. 1933 Mar 31;57(4):527–547. doi: 10.1084/jem.57.4.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ward H. K. OBSERVATIONS ON THE PHAGOCYTOSIS OF THE PNEUMOCOCCUS BY HUMAN WHOLE BLOOD : II. THE NEUTRALIZATION OF THE ANTI-PHAGOCYTIC ACTION OF THE SPECIFIC SOLUBLE SUBSTANCE BY ANTISERUM. J Exp Med. 1930 Apr 30;51(5):685–702. doi: 10.1084/jem.51.5.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wood W. B., Irons E. N. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : II. THE EFFECT OF SULFONAMIDE THERAPY UPON THE PULMONARY LESION OF EXPERIMENTAL PNEUMONIA. J Exp Med. 1946 Sep 30;84(4):365–376. doi: 10.1084/jem.84.4.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wood W. B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : I. THE ACTION OF TYPE SPECIFIC ANTIBODY UPON THE PULMONARY LESION OF EXPERIMENTAL PNEUMONIA. J Exp Med. 1941 Jan 31;73(2):201–222. doi: 10.1084/jem.73.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES