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. 1946 Oct 31;84(5):511–523. doi: 10.1084/jem.84.5.511

CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS

I. THE EFFECT OF BACTERIOPHAGE ADSORPTION ON THE MULTIPLICATION OF ITS HOST, ESCHERICHIA COLI B WITH AN APPENDIX GIVING SOME DATA ON THE COMPOSITION OF THE BACTERIOPHAGE, T2

Seymour S Cohen 1, Thomas F Anderson 1
PMCID: PMC2135662  PMID: 19871584

Abstract

The addition of active or irradiated T2 bacteriophage and T4 bacteriophage to E. coli B stops bacterial multiplication. The respiratory rate and respiratory quotient of the inhibited bacteria remained at the values observed just before infection. A respiratory rate decrease which occasionally appears can be roughly correlated with change of turbidity of the suspension. An intracellular inhibitor of multiplication appears to be liberated into lysates. A similar substance has been separated from normal E. coli B after sonic disintegration. These bacteriostatic preparations contain cytoplasmic granules with lactic acid dehydrogenase activity. The relationship of these phenomena to the interference effect in this system and others has been considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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