Abstract
Experimental pneumonia due to Friedländer's bacillus was produced in white rats by the intrabronchial inoculation of the bacilli suspended in mucin. The pneumonia was lobar in type, was almost uniformly fatal, and simulated the acute form of the natural disease in human beings. The pathogenesis of the pneumonic lesion was studied by examination of microscopic sections of the lungs of animals killed at frequent intervals during the course of the infection. The histologic characteristics of the various stages of the pneumonia were essentially the same as those previously described in experimental pneumococcal (Type I) pneumonia except for the following differences: (1) In isolated areas of the lung in Friedländer's pneumonia many more bacteria were encountered in the alveoli than were ever noted in experimental pneumococcal pneumonia. (2) Abscess formation was common in the late stages of Friedländer's infection, whereas it was not noted in the pneumococcal lesion. (3) Organization of the alveolar exudate, rarely observed in experimental pneumococcal pneumonia, was a prominent feature of the pneumonia due to Friedländer's bacillus. The mechanism of spread of Friedländer's lesion appeared to be the same as that of pneumococcal pneumonia. Likewise there was noted the same phagocytosis of organisms in the lungs of even bacteremic animals dying of the infection.
Full Text
The Full Text of this article is available as a PDF (756.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blake F. G., Cecil R. L. STUDIES ON EXPERIMENTAL PNEUMONIA : II. PATHOLOGY AND PATHOGENESIS OF PNEUMOCOCCUS LOBAR PNEUMONIA IN MONKEYS. J Exp Med. 1920 Mar 31;31(4):445–474. doi: 10.1084/jem.31.4.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Christie R. V., Ehrich W., Binger C. A. AN EXPERIMENTAL STUDY OF DIATHERMY : V. THE ELEVATION OF TEMPERATURE IN THE PNEUMONIC LUNG. J Exp Med. 1928 Apr 30;47(5):741–755. doi: 10.1084/jem.47.5.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lamar R. V., Meltzer S. J. EXPERIMENTAL PNEUMONIA BY INTRABRONCHIAL INSUFFLATION. J Exp Med. 1912 Feb 1;15(2):133–148. doi: 10.1084/jem.15.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Loosli C. G. THE PATHOGENESIS AND PATHOLOGY OF EXPERIMENTAL TYPE I PNEUMOCOCCIC PNEUMONIA IN THE MONKEY. J Exp Med. 1942 Jul 1;76(1):79–92. doi: 10.1084/jem.76.1.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sale L., Smith M. R., Wood W. B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMONIA DUE TO FRIEDLANDER'S BACILLUS : II. THE EFFECT OF SULFONAMIDE CHEMOTHERAPY UPON THE PULMONARY LESION OF EXPERIMENTAL FRIEDLANDER'S BACILLUS PNEUMONIA. J Exp Med. 1947 Aug 31;86(3):249–256. doi: 10.1084/jem.86.3.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith M. R., Wood W. B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMONIA DUE TO FRIEDLADER'S BACILLUS : III. THE ROLE OF "SURFACE PHAGOCYTOSIS" IN THE DESTRUCTION OF THE MICROORGANISMS IN THE LUNG. J Exp Med. 1947 Aug 31;86(3):257–266. doi: 10.1084/jem.86.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood W. B., Irons E. N. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : II. THE EFFECT OF SULFONAMIDE THERAPY UPON THE PULMONARY LESION OF EXPERIMENTAL PNEUMONIA. J Exp Med. 1946 Sep 30;84(4):365–376. doi: 10.1084/jem.84.4.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood W. B., McLeod C., Irons E. N. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : III. FACTORS INFLUENCING THE PHAGOCYTOSIS OF PNEUMOCOCCI IN THE LUNG DURING SULFONAMIDE THERAPY. J Exp Med. 1946 Sep 30;84(4):377–386. doi: 10.1084/jem.84.4.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood W. B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : I. THE ACTION OF TYPE SPECIFIC ANTIBODY UPON THE PULMONARY LESION OF EXPERIMENTAL PNEUMONIA. J Exp Med. 1941 Jan 31;73(2):201–222. doi: 10.1084/jem.73.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood W. B., Smith M. R., Watson B. STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : IV. THE MECHANISM OF PHAGOCYTOSIS IN THE ABSENCE OF ANTIBODY. J Exp Med. 1946 Sep 30;84(4):387–402. doi: 10.1084/jem.84.4.387. [DOI] [PMC free article] [PubMed] [Google Scholar]