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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1947 Nov 30;86(6):477–487. doi: 10.1084/jem.86.6.477

RENAL EFFECTS OF HEMOGLOBIN INFUSIONS IN DOGS IN HEMORRHAGIC SHOCK

Paul B Hamilton 1, Alma Hiller 1, Donald D Van Slyke 1
PMCID: PMC2135756  PMID: 19871692

Abstract

The immediate effects of treating hemorrhagic shock in dogs by replacing lost blood with 7 per cent hemoglobin solution were favorable, both on renal function and on general condition. However, subsequent transitory depression of the urea clearance for several days, shown by some of the treated animals, but not by untreated bled controls, indicates sufficient possibility of renal damage by the hemoglobin solution to prevent its recommendation at present as a blood substitute.

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Selected References

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  1. Hamilton P. B., Farr L. E., Hiller A., Van Slyke D. D. PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION. J Exp Med. 1947 Nov 30;86(6):455–463. doi: 10.1084/jem.86.6.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
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