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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1948 Apr 1;87(4):339–351. doi: 10.1084/jem.87.4.339

STUDIES ON SCRUB TYPHUS (TSUTSUGAMUSHI DISEASE)

III. HETEROGENICITY OF STRAINS OF R. TSUTSUGAMUSHI AS DEMONSTRATED BY CROSS-VACCINATION STUDIES

Fred L Rights 1, Joseph E Smadel 1; Assisted by Elizabeth B. Jackson1
PMCID: PMC2135778  PMID: 18904219

Abstract

Antigenic differences among strains of R. tsutsugamushi are sufficiently great that vaccines prepared from certain strains fail to induce resistance in mice to infection with other strains. Although the results of cross-vaccination tests indicate varying degrees of relationship between a number of the strains, there is no correlation between source of the rickettsia and antigenic pattern of the agent.

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Selected References

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  1. Smadel J. E., Rights F. L., Jackson E. B. STUDIES ON SCRUB TYPHUS : I. SOLUBLE ANTIGEN IN TISSUES AND BODY FLUIDS OF INFECTED MICE AND RATS. J Exp Med. 1946 Jan 31;83(2):133–146. [PMC free article] [PubMed] [Google Scholar]

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