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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1948 Apr 1;87(4):275–282. doi: 10.1084/jem.87.4.275

CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS

V. SOME ADDITIONAL METHODS OF DETERMINING NUTRITIONAL REQUIREMENTS FOR VIRUS MULTIPLICATION

Seymour S Cohen 1, Catherine B Fowler 1
PMCID: PMC2135782  PMID: 18904213

Abstract

Omission of a single constituent from a chemically defined medium approximating the virus growth-promoting properties of broth affects virus production in infected bacteria. This may be estimated by the one-step growth technique and the course of desoxyribose nucleic acid synthesis. Nine amino acids and one purine have been shown to be important by these tests. A combination of all constituents observed to be important by the single supplement and single omission techniques has approximated the virus growth-promoting properties of broth. Certain anomalous results have been commented upon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen S. S., Anderson T. F. CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : I. THE EFFECT OF BACTERIOPHAGE ADSORPTION ON THE MULTIPLICATION OF ITS HOST, ESCHERICHIA COLI B WITH AN APPENDIX GIVING SOME DATA ON THE COMPOSITION OF THE BACTERIOPHAGE, T2. J Exp Med. 1946 Oct 31;84(5):511–523. doi: 10.1084/jem.84.5.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cohen S. S., Fowler C. B. CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM. J Exp Med. 1947 May 31;85(6):771–784. doi: 10.1084/jem.85.6.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FOWLER C. B., COHEN S. S. Chemical studies in host-virus interactions; a method of determining nutritional requirements for bacterial virus multiplication. J Exp Med. 1948 Apr 1;87(4):259–274. doi: 10.1084/jem.87.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]

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