Abstract
Human sera taken at various stages of mumps have been analyzed in regard to their reactivity with two serologically distinct complement fixation antigens which were derived from the infected chick embryo. Antibodies to the soluble or S antigen appear earlier in the disease and, as a rule, reach high levels before antibodies against the virus-bound or V antigen commence to rise. In early convalescence, both antibodies reach high levels. Subsequently antibodies against the S antigen decrease usually at a faster rate than those against V, so that after a period of several years, frequently only anti-V may be left. These findings were found helpful in diagnostic procedures. The use of both the V and S antigens has permitted the early diagnosis of manifestations of mumps in the absence of parotitis, such as meningoencephalitis, since the finding of high levels of anti-S and of low titers of, or no, anti-V is considered diagnostically significant for the first few days of illness. For the determination of resistance the use of the V antigen appears more useful. Following vaccination or skin testing, antibodies against both antigens may develop; those against V increase more regularly and to higher titers than those against S.
Full Text
The Full Text of this article is available as a PDF (801.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Enders J. F., Cohen S., Kane L. W. IMMUNITY IN MUMPS : II. THE DEVELOPMENT OF COMPLEMENT-FIXING ANTIBODY AND DERMAL HYPERSENSITIVITY IN HUMAN BEINGS FOLLOWING MUMPS. J Exp Med. 1945 Jan 1;81(1):119–135. doi: 10.1084/jem.81.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Enders J. F., Kane L. W., Cohen S., Levens J. H. IMMUNITY IN MUMPS : I. EXPERIMENTS WITH MONKEYS (MACACUS MULATTA). THE DEVELOPMENT OF COMPLEMENT-FIXING ANTIBODY FOLLOWING INFECTION AND EXPERIMENTS ON IMMUNIZATION BY MEANS OF INACTIVATED VIRUS AND CONVALESCENT HUMAN SERUM. J Exp Med. 1945 Jan 1;81(1):93–117. doi: 10.1084/jem.81.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Enders J. F., Kane L. W., Maris E. P., Stokes J. IMMUNITY IN MUMPS : V. THE CORRELATION OF THE PRESENCE OF DERMAL HYPERSENSITIVITY AND RESISTANCE TO MUMPS. J Exp Med. 1946 Sep 30;84(4):341–364. doi: 10.1084/jem.84.4.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kane L. W., Enders J. F. IMMUNITY IN MUMPS : III. THE COMPLEMENT FIXATION TEST AS AN AID IN THE DIAGNOSIS OF MUMPS MENINGOENCEPHALITIS. J Exp Med. 1945 Jan 1;81(1):137–150. doi: 10.1084/jem.81.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levens J. H., Enders J. F. THE HEMOAGGLUTINATIVE PROPERTIES OF AMNIOTIC FLUID FROM EMBRYONATED EGGS INFECTED WITH MUMPS VIRUS. Science. 1945 Aug 3;102(2640):117–120. doi: 10.1126/science.102.2640.117. [DOI] [PubMed] [Google Scholar]
- Maris E. P., Enders J. F., Stokes J., Kane L. W. IMMUNITY IN MUMPS : IV. THE CORRELATION OF THE PRESENCE OF COMPLEMENT-FIXING ANTIBODY AND RESISTANCE TO MUMPS IN HUMAN BEINGS. J Exp Med. 1946 Sep 30;84(4):323–339. doi: 10.1084/jem.84.4.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stokes J., Enders J. F., Maris E. P., Kane L. W. IMMUNITY IN MUMPS : VI. EXPERIMENTS ON THE VACCINATION OF HUMAN BEINGS WITH FORMOLIZED MUMPS VIRUS. J Exp Med. 1946 Oct 31;84(5):407–428. doi: 10.1084/jem.84.5.407. [DOI] [PMC free article] [PubMed] [Google Scholar]