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. 1948 Oct 1;88(4):463–484. doi: 10.1084/jem.88.4.463

REACTIONS BETWEEN INFLUENZA VIRUS AND A COMPONENT OF ALLANTOIC FLUID

Paul H Hardy Jr 1, Frank L Horsfall Jr 1
PMCID: PMC2135833  PMID: 18884904

Abstract

Evidence is presented which shows that there is a component present in normal allantoic fluid, probably mucoprotein in nature, capable of combining with influenza A virus (PR8), and that following combination between this component and the virus only partial dissociation of the complex occurs. Evidence is also presented which strongly suggests that the component is present in virus-infected allantoic fluid in which it is in part combined with the virus and in part free although altered by viral action. The probability that the component is present as well in highly purified preparations of influenza virus, and its effect upon various reactions obtained with this agent are discussed.

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Selected References

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  1. Claude A. SPREADING PROPERTIES OF LEECH EXTRACTS AND THE FORMATION OF LYMPH. J Exp Med. 1937 Aug 31;66(3):353–366. doi: 10.1084/jem.66.3.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Deburgh P. M., Yu P. C., Howe C., Bovarnick M. PREPARATION FROM HUMAN RED CELLS OF A SUBSTANCE INHIBITING VIRUS HEMAGGLUTINATION. J Exp Med. 1948 Jan 1;87(1):1–9. doi: 10.1084/jem.87.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Francis T. DISSOCIATION OF HEMAGGLUTINATING AND ANTIBODY-MEASURING CAPACITIES OF INFLUENZA VIRUS. J Exp Med. 1947 Jan 1;85(1):1–7. doi: 10.1084/jem.85.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Friedewald W. F., Miller E. S., Whatley L. R. THE NATURE OF NON-SPECIFIC INHIBITION OF VIRUS HEMAGGLUTINATION. J Exp Med. 1947 Jun 30;86(1):65–75. doi: 10.1084/jem.86.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HIRST G. K. The nature of the virus receptors of red cells; the effect of partial heat inactivation of influenza virus on the destruction of red cell receptors and the use of inactivated virus in the measurement of serum inhibitor. J Exp Med. 1948 Apr 1;87(4):315–328. doi: 10.1084/jem.87.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heinmets F. Studies with the Electron Microscope on the Interaction of Red Cells and Influenza Virus. J Bacteriol. 1948 Jun;55(6):823–831. doi: 10.1128/jb.55.6.823-831.1948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hirst G. K. ADSORPTION OF INFLUENZA HEMAGGLUTININS AND VIRUS BY RED BLOOD CELLS. J Exp Med. 1942 Aug 1;76(2):195–209. doi: 10.1084/jem.76.2.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hirst G. K. THE QUANTITATIVE DETERMINATION OF INFLUENZA VIRUS AND ANTIBODIES BY MEANS OF RED CELL AGGLUTINATION. J Exp Med. 1942 Jan 1;75(1):49–64. doi: 10.1084/jem.75.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kass E. H., Seastone C. V. THE ROLE OF THE MUCOID POLYSACCHARIDE (HYALURONIC ACID) IN THE VIRULENCE OF GROUP A HEMOLYTIC STREPTOCOCCI. J Exp Med. 1944 Mar 1;79(3):319–330. doi: 10.1084/jem.79.3.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Knight C. A. PRECIPITIN REACTIONS OF HIGHLY PURIFIED INFLUENZA VIRUSES AND RELATED MATERIALS. J Exp Med. 1946 Mar 31;83(4):281–294. [PMC free article] [PubMed] [Google Scholar]
  11. Knight C. A. THE NUCLEIC ACID AND CARBOHYDRATE OF INFLUENZA VIRUS. J Exp Med. 1947 Jan 1;85(1):99–116. doi: 10.1084/jem.85.1.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Meyer K., Chaffee E., Hobby G. L., Dawson M. H. HYALURONIDASES OF BACTERIAL AND ANIMAL ORIGIN. J Exp Med. 1941 Feb 28;73(3):309–326. doi: 10.1084/jem.73.3.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Meyer K., Hobby G. L., Chaffee E., Dawson M. H. THE HYDROLYSIS OF HYALURONIC ACID BY BACTERIAL ENZYMES. J Exp Med. 1940 Jan 31;71(2):137–146. doi: 10.1084/jem.71.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]

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