Abstract
The factor in brain tissue which induces acute disseminated encephalomyelitis, when injected into rhesus monkeys as an emulsion with adjuvants, has been found in human, monkey, rabbit, and chicken brain but is absent from frog and fish brain. It is unaffected by fixation of the brain in formalin, by boiling, and by treatment with ultrasound. It is present in the spinal cord of 3 day old rabbits but does not appear in the rabbit cerebrum until about the 12th day of life; in this respect it parallels the laying down of myelin. Attempts to produce the encephalomyelitis passively with large quantities of serum or of cell exudates, and suspensions of cells from spleen and lymph node from monkeys with encephalomyelitis, were unsuccessful.
Full Text
The Full Text of this article is available as a PDF (668.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Kabat E. A., Wolf A., Bezer A. E. Rapid Production of Acute Disseminated Encephalomyelitis in Rhesus Monkeys by Injection of Brain Tissue With Adjuvants. Science. 1946 Oct 18;104(2703):362–363. doi: 10.1126/science.104.2703.362. [DOI] [PubMed] [Google Scholar]
- Kolb L. C., Bolton B. ANTIBODIES TO BRAIN AND THEIR RELATION TO DEMYELINIZATION. J Neurol Psychiatry. 1940 Apr;3(2):111–114. doi: 10.1136/jnnp.3.2.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morgan I. M. ALLERGIC ENCEPHALOMYELITIS IN MONKEYS IN RESPONSE TO INJECTION OF NORMAL MONKEY NERVOUS TISSUE. J Exp Med. 1947 Jan 1;85(1):131–140. doi: 10.1084/jem.85.1.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rivers T. M., Schwentker F. F. ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS. J Exp Med. 1935 Apr 30;61(5):689–702. doi: 10.1084/jem.61.5.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwentker F. F., Rivers T. M. THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAIN. J Exp Med. 1934 Oct 31;60(5):559–574. doi: 10.1084/jem.60.5.559. [DOI] [PMC free article] [PubMed] [Google Scholar]