Abstract
The manifestations and course of an hereditary disease of the rabbit are reported. The condition is present at birth and is invariably fatal, generally in the 4th and 5th weeks of age. Retardation and eventual cessation of growth with marked reduction in size are conspicuous characteristic symptoms. The condition, which first occurred in the backcross progeny of a pure bred Dutch male rabbit, is inherited. It is determined by the expression of a simple recessive unit factor, affected individuals being homozygous for the factor. Rabbits heterozygous for the factor are identified only by appropriate breeding tests. The condition is not sex-linked. The disease has a remarkable resemblance to osteopetrosis or marble bone disease of infants and children with respect to signs and general course and also, as may be stated in anticipation of later discussions (5, 6), to the characteristic abnormal condition of the skeleton.
Full Text
The Full Text of this article is available as a PDF (1.3 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown W. H., Pearce L. HEREDITARY ACHONDROPLASIA IN THE RABBIT : I. PHYSICAL APPEARANCE AND GENERAL FEATURES. J Exp Med. 1945 Sep 30;82(4):241–260. doi: 10.1084/jem.82.4.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greene H. S., Saxton J. A. HEREDITARY BRACHYDACTYLIA AND ALLIED ABNORMALITIES IN THE RABBIT. J Exp Med. 1939 Jan 31;69(2):301–314. doi: 10.1084/jem.69.2.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nussey A. M. Osteopetrosis. Arch Dis Child. 1938 Jun;13(74):161–172. doi: 10.1136/adc.13.74.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PEARCE L. Hereditary osteopetrosis of the rabbit; X-ray, hematologic, and chemical observations. J Exp Med. 1948 Dec;88(6):597–620. doi: 10.1084/jem.88.6.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearce L., Brown W. H. HEREDITARY ACHONDROPLASIA IN THE RABBIT : II. PATHOLOGIC ASPECTS. J Exp Med. 1945 Sep 30;82(4):261–280. doi: 10.1084/jem.82.4.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearce L., Brown W. H. HEREDITARY ACHONDROPLASIA IN THE RABBIT : III. GENETIC ASPECTS; GENERAL CONSIDERATIONS. J Exp Med. 1945 Sep 30;82(4):281–295. doi: 10.1084/jem.82.4.281. [DOI] [PMC free article] [PubMed] [Google Scholar]