Abstract
The isolation and characterization of a type-specific M protein from pneumococcus are described. This protein is similar chemically in all respects studied to the M proteins of group A streptococci. No immunological crossreactions have been observed, however, between M proteins of the two species. Strains of capsular type I pneumococcus have been encountered which contain different M proteins. The same is true for capsular type II pneumococcus. It is apparent, therefore, that the capsular polysaccharides and M proteins can vary independently of each other.
Full Text
The Full Text of this article is available as a PDF (636.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Avery O. T., Morgan H. J. IMMUNOLOGICAL REACTIONS OF THE ISOLATED CARBOHYDRATE AND PROTEIN OF PNEUMOCOCCUS. J Exp Med. 1925 Aug 31;42(3):347–353. doi: 10.1084/jem.42.3.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goebel W. F., Adams M. H. THE IMMUNOLOGICAL PROPERTIES OF THE HETEROPHILE ANTIGEN AND SOMATIC POLYSACCHARIDE OF PNEUMOCOCCUS. J Exp Med. 1943 May 1;77(5):435–449. doi: 10.1084/jem.77.5.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Kabat E. A. CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : IV. QUANTITATIVE DATA ON PNEUMOCOCCUS R (DAWSON S)- ANTI-R (S) SYSTEMS. J Exp Med. 1938 Mar 31;67(4):545–550. doi: 10.1084/jem.67.4.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lancefield R. C. STUDIES ON THE ANTIGENIC COMPOSITION OF GROUP A HEMOLYTIC STREPTOCOCCI : I. EFFECTS OF PROTEOLYTIC ENZYMES ON STREPTOCOCCAL CELLS. J Exp Med. 1943 Dec 1;78(6):465–476. doi: 10.1084/jem.78.6.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swift H. F., Wilson A. T., Lancefield R. C. TYPING GROUP A HEMOLYTIC STREPTOCOCCI BY M PRECIPITIN REACTIONS IN CAPILLARY PIPETTES. J Exp Med. 1943 Aug 1;78(2):127–133. doi: 10.1084/jem.78.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]