Abstract
The double strain inoculation (DSI) method of testing for natural resistance to infection has been examined in the instance of mouse salmonellosis. The DSI method has been found capable of detecting differences in natural resistance due to genetic as well as nutritional causes. A difference in response to Salmonella infection was found for the first time between the two "susceptible" inbred mouse strains, BSVR and BSVS. Whereas BSVS mice for the most part survived an intraperitoneal injection of 103 "avirulent" S. typhimurium, BSVR mice all succumbed. The relationship of the DSI test to the usual single infection test has been discussed and it is suggested that such single infection tests are special cases of the DSI test, since they involve a heterogeneous bacterial population which can be considered as a mixture of cultures of differing virulence and in which, by a single injection, the usual time interval between the two injections of the DSI method has been reduced to 0.
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Selected References
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- Lynch C. J. AN OUTBREAK OF MOUSE TYPHOID AND ITS ATTEMPTED CONTROL BY VACCINATION. J Exp Med. 1922 Jun 30;36(1):15–23. doi: 10.1084/jem.36.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pike R. M., Mackenzie G. M. Virulence of Salmonella typhimurium: I. Analysis of Experimental Infection in Mice with Strains of High and Low Virulence. J Bacteriol. 1940 Aug;40(2):171–195. doi: 10.1128/jb.40.2.171-195.1940. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHNEIDER H. A. Nutrition of the host and natural resistance to infection; the conditions necessary for the maximal effect of diet. J Exp Med. 1948 Feb 1;87(2):103–118. doi: 10.1084/jem.87.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schneider H. A. NUTRITION OF THE HOST AND NATURAL RESISTANCE TO INFECTION : II. THE DIETARY EFFECT AS CONDITIONED BY THE HETEROGENEITY OF THE TEST PATHOGEN POPULATION. J Exp Med. 1946 Sep 30;84(4):305–322. doi: 10.1084/jem.84.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schneider H. A., Webster L. T. NUTRITION OF THE HOST AND NATURAL RESISTANCE TO INFECTION : I. THE EFFECT OF DIET ON THE RESPONSE OF SEVERAL GENOTYPES OF MUS MUSCULUS TO SALMONELLA ENTERITIDIS INFECTION. J Exp Med. 1945 Apr 1;81(4):359–384. doi: 10.1084/jem.81.4.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T. INHERITANCE OF RESISTANCE OF MICE TO ENTERIC BACTERIAL AND NEUROTROPIC VIRUS INFECTIONS. J Exp Med. 1937 Jan 31;65(2):261–286. doi: 10.1084/jem.65.2.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T. INHERITED AND ACQUIRED FACTORS IN RESISTANCE TO INFECTION : I. DEVELOPMENT OF RESISTANT AND SUSCEPTIBLE LINES OF MICE THROUGH SELECTIVE BREEDING. J Exp Med. 1933 Apr 30;57(5):793–817. doi: 10.1084/jem.57.5.793. [DOI] [PMC free article] [PubMed] [Google Scholar]