Abstract
Sterile inflammation induced by repeated subcutaneous injections of turpentine in non-anemic, non-iron—deficient dogs, leads to a fall in plasma iron concentration, the development of a moderate anemia, and a marked delay in the uptake by the red blood cells of intravenous radioiron. Similar periods of inflammation in anemic, iron-deficient dogs on a diet low in iron cause no increase in the degree of anemia and no inhibition of red blood cell uptake of intravenous radioiron. Radioiron appears only in traces in abscess exudates. Intravenous iron disappearance curves following a single injection are uninfluenced by sterile inflammation in either anemic or non-anemic dogs. The impairment of hemoglobin synthesis caused by inflammation is at most a relative matter, since the anemia that develops is seldom severe or progressive, and since the inhibition can be overcome if the marrow is sufficiently stimulated by the demands of a severe continuing anemia.
Full Text
The Full Text of this article is available as a PDF (483.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gibson J. G., Evelyn K. A. CLINICAL STUDIES OF THE BLOOD VOLUME. IV. ADAPTATION OF THE METHOD TO THE PHOTOELECTRIC MICROCOLORIMETER. J Clin Invest. 1938 Mar;17(2):153–158. doi: 10.1172/JCI100938. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gibson J. G., Peacock W. C., Seligman A. M., Sack T. CIRCULATING RED CELL VOLUME MEASURED SIMULTANEOUSLY BY THE RADIOACTIVE IRON AND DYE METHODS. J Clin Invest. 1946 Nov;25(6):838–847. doi: 10.1172/JCI101771. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenberg G. R., Ashenbrucker H., Lauritsen M., Wintrobe M. M. THE ANEMIA OF INFECTION. IV. THE LACK OF RELATIONSHIP BETWEEN THE DIVERSION OF IRON FROM THE PLASMA AND THE ORIGIN OF THE ANEMIA. J Clin Invest. 1947 Jan;26(1):114–120. doi: 10.1172/JCI101783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hahn P. F., Ross J. F., Bale W. F., Balfour W. M., Whipple G. H. RED CELL AND PLASMA VOLUMES (CIRCULATING AND TOTAL) AS DETERMINED BY RADIO IRON AND BY DYE. J Exp Med. 1942 Jan 31;75(2):221–232. doi: 10.1084/jem.75.2.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROBINSON J. C., JAMES G. W., 3rd, KARK R. M. The effect of oral therapy with cobaltous chloride on the blood of patients suffering with chronic suppurative infection. N Engl J Med. 1949 May 12;240(19):749–753. doi: 10.1056/NEJM194905122401902. [DOI] [PubMed] [Google Scholar]
- Robscheit-Robbins F. S., Whipple G. H. INFECTION AND INTOXICATION : THEIR INFLUENCE UPON HEMOGLOBIN PRODUCTION IN EXPERIMENTAL ANEMIA. J Exp Med. 1936 Apr 30;63(5):767–787. doi: 10.1084/jem.63.5.767. [DOI] [PMC free article] [PubMed] [Google Scholar]