Skip to main content
NCBI home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1950 Nov 30;92(6):527–543. doi: 10.1084/jem.92.6.527

STUDIES ON BACTERIOPHAGE

II. INHIBITION OF LYSIS OF ESCHERICHIA COLI B BY THE SOMATIC ANTIGEN OF PHASE II SHIGELLA SONNEI

Walther F Goebel 1
PMCID: PMC2135995  PMID: 14784535

Abstract

By serological means it has been shown that E. coli B contains an antigen closely related to the protein-lipocarbohydrate complex of Phase II Sh. sonnei. Lysis of E. coli B by three of the T viruses, T3, T4, and T7, can be inhibited by the Phase II dysentery antigen. It has been suggested that the receptor of E. coli B with which these viruses combine is this newly described antigenic component. Two variants of the virus T3 have also been described, in stocks which have been treated with the Phase II antigen. One of these variants infects both Phase II Sh. sonnei and E. coli B, and the other infects only the latter microorganism; neither of the two variants is inhibited by concentrations of the Phase II antigen of 1 mg. per cc. The distinctive properties of the variants are not hereditary.

Full Text

The Full Text of this article is available as a PDF (879.0 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avery O. T., Goebel W. F. CHEMOIMMUNOLOGICAL STUDIES ON THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : I. THE ISOLATION AND PROPERTIES OF THE ACETYL POLYSACCHARIDE OF PNEUMOCOCCUS TYPE I. J Exp Med. 1933 Nov 30;58(6):731–755. doi: 10.1084/jem.58.6.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BAKER E. E., GOEBEL W. F., PERLMAN E. The specific antigens of variants of Shigella sonnei. J Exp Med. 1949 Mar;89(3):325–338. doi: 10.1084/jem.89.3.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Demerec M, Fano U. Bacteriophage-Resistant Mutants in Escherichia Coli. Genetics. 1945 Mar;30(2):119–136. doi: 10.1093/genetics/30.2.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GINSBERG H. S., GOEBEL W. F., HORSFALL F. L., Jr The effect of polysaccharides on the reaction between erythrocytes and viruses, with particular reference to mumps virus. J Exp Med. 1948 May 1;87(5):411–424. doi: 10.1084/jem.87.5.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Heidelberger M., Kabat E. A., Shrivastava D. L. A QUANTITATIVE STUDY OF THE CROSS REACTION OF TYPES III AND VIII PNEUMOCOCCI IN HORSE AND RABBIT ANTISERA. J Exp Med. 1937 Mar 31;65(4):487–496. doi: 10.1084/jem.65.4.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Horsfall F. L., McCarty M. THE MODIFYING EFFECTS OF CERTAIN SUBSTANCES OF BACTERIAL ORIGIN ON THE COURSE OF INFECTION WITH PNEUMONIA VIRUS OF MICE (PVM). J Exp Med. 1947 May 31;85(6):623–646. doi: 10.1084/jem.85.6.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MILLER E. M., GOEBEL W. F. Role of cofactors in the inhibition of bacterial viruses by the somatic antigens of Shigella sonnei. Nature. 1949 Oct 29;164(4174):744–744. doi: 10.1038/164744a0. [DOI] [PubMed] [Google Scholar]
  8. MILLER E. M., GOEBEL W. F. Studies on bacteriophage; the relationship between the somatic antigens of Shigella sonnei and their susceptibilitv to bacterial viruses. J Exp Med. 1949 Sep;90(3):255–265. doi: 10.1084/jem.90.3.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MUSHIN R. A new antigenic relationship among faecal bacilli due to a common beta antigen. J Hyg (Lond) 1949 Sep;47(3):227-35, pl. doi: 10.1017/s0022172400014534. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES