Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1950 Jun 1;91(6):567–572. doi: 10.1084/jem.91.6.567

RENIN PROTEINURIA IN THE RAT

II. EVIDENCE THAT RENIN DOES NOT INTERFERE WITH THE TUBULAR RESORPTION OF PURIFIED HUMAN HEMOGLOBIN OR BOVINE ALBUMIN

L J Rather 1, T Addis 1
PMCID: PMC2136011  PMID: 15422084

Abstract

The intraperitoneal injection of renin together with purified human hemoglobin or bovine albumin increases the weight of the kidneys and increases the number of athrocytosed particles of protein in the cells of the proximal convoluted tubules. In the case of bovine albumin administration there is a threefold increase in protein excretion in those rats given renin as compared with those given bovine albumin alone. A possible explanation of these effects is given.

Full Text

The Full Text of this article is available as a PDF (518.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADDIS T., BARRETT E. Renin proteinuria in the rat; the relation between the proteinuria and the pressor effect of renin. J Exp Med. 1949 Feb;89(2):131–140. doi: 10.1084/jem.89.2.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. OLIVER J. The structure of the metabolic process in the nephron. J Mt Sinai Hosp N Y. 1948 Nov–Dec;15(4):175–222. [PubMed] [Google Scholar]
  3. Smetana H., Johnson F. R. The Origin of Colloid and Lipoid Droplets in the Epithelial Cells of the Renal Tubules. Am J Pathol. 1942 Nov;18(6):1029–1049. [PMC free article] [PubMed] [Google Scholar]
  4. Smetana H. The Permeability of the Renal Glomeruli of Several Mammalian Species to Labelled Proteins. Am J Pathol. 1947 Mar;23(2):255–267. [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES