Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1950 Jul 1;92(1):1–9. doi: 10.1084/jem.92.1.1

RELATION OF VIRULENCE OF PNEUMOCOCCAL STRAINS FOR MICE TO THE QUANTITY OF CAPSULAR POLYSACCHARIDE FORMED IN VITRO

Colin M MacLeod 1, Marjorie R Krauss 1
PMCID: PMC2136027  PMID: 15422092

Abstract

The amount of capsular polysaccharide formed in vitro by strains of pneumococcus types II, III, and VII of different virulence for mice has been measured by quantitative precipitin reactions. The quantity produced by strains of high virulence was greater for all three types than that formed by moderately virulent or avirulent strains. It is suggested that an important factor concerned in variations of virulence of pneumococci for mice is the genetic apparatus that controls the amount of SSS synthesized by the cells.

Full Text

The Full Text of this article is available as a PDF (473.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : II. CONDITIONS FOR QUANTITATIVE PRECIPITATION OF ANTIBODY IN HORSE SERA. J Exp Med. 1935 Mar 31;61(4):559–562. doi: 10.1084/jem.61.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Heidelberger M., Kendall F. E. THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : III. A QUANTITATIVE STUDY AND A THEORY OF THE REACTION MECHANISM. J Exp Med. 1935 Mar 31;61(4):563–591. doi: 10.1084/jem.61.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Macleod C. M., Krauss M. R. STEPWISE INTRATYPE TRANSFORMATION OF PNEUMOCOCCUS FROM R TO S BY WAY OF A VARIANT INTERMEDIATE IN CAPSULAR POLYSACCHARIDE PRODUCTION. J Exp Med. 1947 Nov 30;86(6):439–452. doi: 10.1084/jem.86.6.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. TAYLOR H. E. Additive effects of certain transforming agents from some variants of pneumococcus. J Exp Med. 1949 Apr 1;89(4):399–424. doi: 10.1084/jem.89.4.399. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES