Abstract
The control of iron absorption appears to reside in the mucosa of the gastrointestinal tract. The normal dog absorbs very little iron, but the anemic iron-depleted dog may absorb 10 to 20 times as much. This "mucosal block" of the normal dog probably is due largely to iron stores in the mucosa. "Mucosal block" can be effected in the anemic iron-depleted dog by feeding of iron salts, but the degree of "mucosal block" under these conditions never reaches the high degree of "mucosal block" in the normal dog. Rapid movement of iron through the mucosa may explain the short duration of "mucosal block" due to iron feeding in the anemic iron-depleted dogs (18 to 20 hours, Fig. 1). The colon absorbs very little iron under the conditions described. The stomach and duodenum seem to be most active in its absorption. This suggests the existence of a gradient in the capacity of the gastrointestinal tract to absorb iron.
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Selected References
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- Gibson J. G., Evelyn K. A. CLINICAL STUDIES OF THE BLOOD VOLUME. IV. ADAPTATION OF THE METHOD TO THE PHOTOELECTRIC MICROCOLORIMETER. J Clin Invest. 1938 Mar;17(2):153–158. doi: 10.1172/JCI100938. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hahn P. F., Bale W. F., Ross J. F., Balfour W. M., Whipple G. H. RADIOACTIVE IRON ABSORPTION BY GASTRO-INTESTINAL TRACT : INFLUENCE OF ANEMIA, ANOXIA, AND ANTECEDENT FEEDING DISTRIBUTION IN GROWING DOGS. J Exp Med. 1943 Sep 1;78(3):169–188. doi: 10.1084/jem.78.3.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hahn P. F., Ross J. F., Bale W. F., Whipple G. H. THE UTILIZATION OF IRON AND THE RAPIDITY OF HEMOGLOBIN FORMATION IN ANEMIA DUE TO BLOOD LOSS. J Exp Med. 1940 May 31;71(6):731–736. doi: 10.1084/jem.71.6.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KINNEY T. D., HEGSTED D. M., FINCH C. A. The influence of diet on iron absorption; the pathology of iron excess. J Exp Med. 1949 Aug 1;90(2):137–146. doi: 10.1084/jem.90.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- YUILE C. L., BLY C. G. Plasma and red cell radioiron following intravenous injection; turpentine abscesses in normal and anemic dogs. J Exp Med. 1949 Oct;90(4):273–282. doi: 10.1084/jem.90.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- YUILE C. L., HAYDEN J. W., BUSH J. A., TESLUK H., STEWART W. B. Plasma iron and saturation of plasma iron-binding protein in dogs as related to the gastro-intestinal absorption of radioiron. J Exp Med. 1950 Oct 1;92(4):367–373. doi: 10.1084/jem.92.4.367. [DOI] [PMC free article] [PubMed] [Google Scholar]