Abstract
The administration of adrenocorticotrophic hormone and of cortisone was found to result in a reduction in the concentration of antipneumococcal antibody in the circulation of rabbits. This reduction occurred both when the hormones were administered at the beginning of immunization and after immunization was well advanced. Marked atrophic changes in lymphoid tissue and a diminution in the number of various types of mononuclear cells followed upon the hormone administration. The possible bearing of these observations on theories concerning the sites of antibody production is discussed.
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Selected References
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- ABRAMS A., COHEN P. P. Electrophoretic and chemical characterization of human lymphoid tissue and calf thymus. J Biol Chem. 1949 Jan;177(1):439–449. [PubMed] [Google Scholar]
- FISCHEL E. E., LeMAY M., KABAT E. A. The effect of adrenocorticotrophic hormone and X-ray on the amount of circulating antibody. J Immunol. 1949 Jan;61(1):89–93. [PubMed] [Google Scholar]
- FISCHEL E. E. The role of allergy in the pathogenesis of rheumatic fever. Am J Med. 1949 Dec;7(6):772–793. doi: 10.1016/0002-9343(49)90417-9. [DOI] [PubMed] [Google Scholar]
- HARRIS T. N., MOORE D. H., FARBER M. Physicochemical studies on lymph and lymphocyte extracts from normal and stimulated lymphatic tissue. J Biol Chem. 1949 May;179(1):369–376. [PubMed] [Google Scholar]
- Heidelberger M., Kabat E. A. CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : I. A METHOD. J Exp Med. 1934 Oct 31;60(5):643–653. doi: 10.1084/jem.60.5.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kass E. H. THE OCCURRENCE OF NORMAL SERUM GAMMA-GLOBULIN IN HUMAN LYMPHOCYTES. Science. 1945 Mar 30;101(2622):337–338. doi: 10.1126/science.101.2622.337. [DOI] [PubMed] [Google Scholar]
- McMaster P. D., Hudack S. S. THE FORMATION OF AGGLUTININS WITHIN LYMPH NODES. J Exp Med. 1935 May 31;61(6):783–805. doi: 10.1084/jem.61.6.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAGAN C., GROKOEST A. W., BOOTS R. H. Effect of adrenocorticotrophic hormone on rheumatoid arthritis. Am J Med. 1949 Dec;7(6):741–750. doi: 10.1016/0002-9343(49)90412-x. [DOI] [PubMed] [Google Scholar]
- Sabin F. R. CELLULAR REACTIONS TO A DYE-PROTEIN WITH A CONCEPT OF THE MECHANISM OF ANTIBODY FORMATION. J Exp Med. 1939 Jun 30;70(1):67–82. doi: 10.1084/jem.70.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stoerk H. C., Eisen H. N., John H. M. IMPAIRMENT OF ANTIBODY RESPONSE IN PYRIDOXINE-DEFICIENT RATS. J Exp Med. 1947 Mar 31;85(4):365–371. doi: 10.1084/jem.85.4.365. [DOI] [PMC free article] [PubMed] [Google Scholar]