Abstract
Radioiron uptake from 59FeCl3 by Streptococcus mutans OMZ176 was increased by anaerobiosis, sodium ascorbate, and phenazine methosulfate (PMS), although there was a 10-min lag before PMS stimulation was evident. The reductant ascorbate may have provided ferrous iron. The PMS was reduced by the cells, and the reduced PMS then may have generated ferrous iron for transport; reduced PMS also may have depleted dissolved oxygen. We conclude that S. mutans transports only ferrous iron, utilizing reductants furnished by glucose metabolism to reduce iron prior to its uptake.
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Selected References
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- Actis L. A., Fish W., Crosa J. H., Kellerman K., Ellenberger S. R., Hauser F. M., Sanders-Loehr J. Characterization of anguibactin, a novel siderophore from Vibrio anguillarum 775(pJM1). J Bacteriol. 1986 Jul;167(1):57–65. doi: 10.1128/jb.167.1.57-65.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Aranha H., Strachan R. C., Arceneaux J. E., Byers B. R. Effect of trace metals on growth of Streptococcus mutans in a teflon chemostat. Infect Immun. 1982 Feb;35(2):456–460. doi: 10.1128/iai.35.2.456-460.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arnold R. R., Russell J. E., Champion W. J., Brewer M., Gauthier J. J. Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation. Infect Immun. 1982 Mar;35(3):792–799. doi: 10.1128/iai.35.3.792-799.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cole J. A. A biochemical approach to the control of dental caries. Biochem Soc Trans. 1977;5(4):1232–1239. doi: 10.1042/bst0051232. [DOI] [PubMed] [Google Scholar]
- Cowart R. E., Foster B. G. Differential effects of iron on the growth of Listeria monocytogenes: minimum requirements and mechanism of acquisition. J Infect Dis. 1985 Apr;151(4):721–730. doi: 10.1093/infdis/151.4.721. [DOI] [PubMed] [Google Scholar]
- Cox C. D. Role of pyocyanin in the acquisition of iron from transferrin. Infect Immun. 1986 Apr;52(1):263–270. doi: 10.1128/iai.52.1.263-270.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans W. C. Oxidation of phenol and benzoic acid by some soil bacteria. Biochem J. 1947;41(3):373–382. doi: 10.1042/bj0410373. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fujiwara S., Kobayashi S., Nakayama H. Development of a minimal medium for Streptococcus mutans. Arch Oral Biol. 1978;23(7):601–602. doi: 10.1016/0003-9969(78)90280-7. [DOI] [PubMed] [Google Scholar]
- Hamada S., Slade H. D. Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev. 1980 Jun;44(2):331–384. doi: 10.1128/mr.44.2.331-384.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Martin M. E., Byers B. R., Olson M. O., Salin M. L., Arceneaux J. E., Tolbert C. A Streptococcus mutans superoxide dismutase that is active with either manganese or iron as a cofactor. J Biol Chem. 1986 Jul 15;261(20):9361–9367. [PubMed] [Google Scholar]
- Martin M. E., Strachan R. C., Aranha H., Evans S. L., Salin M. L., Welch B., Arceneaux J. E., Byers B. R. Oxygen toxicity in Streptococcus mutans: manganese, iron, and superoxide dismutase. J Bacteriol. 1984 Aug;159(2):745–749. doi: 10.1128/jb.159.2.745-749.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neilands J. B. Iron absorption and transport in microorganisms. Annu Rev Nutr. 1981;1:27–46. doi: 10.1146/annurev.nu.01.070181.000331. [DOI] [PubMed] [Google Scholar]
- Thomas E. L., Pera K. A. Oxygen metabolism of Streptococcus mutans: uptake of oxygen and release of superoxide and hydrogen peroxide. J Bacteriol. 1983 Jun;154(3):1236–1244. doi: 10.1128/jb.154.3.1236-1244.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Young I. G. Preparation of enterochelin from Escherichia coli. Prep Biochem. 1976;6(2-3):123–131. doi: 10.1080/00327487608061607. [DOI] [PubMed] [Google Scholar]
- ZAUGG W. S. SPECTROSCOPIC CHARACTERISTICS AND SOME CHEMICAL PROPERTIES OF N-METHYLPHENAZINIUM METHYL SULFATE (PHENAZINE METHOSULFATE) AND PYOCYANINE AT THE SEMIQUIDNOID OXIDATION LEVEL. J Biol Chem. 1964 Nov;239:3964–3970. [PubMed] [Google Scholar]