Abstract
Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.
Full Text
The Full Text of this article is available as a PDF (296.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Elliott S. D. A PROTEOLYTIC ENZYME PRODUCED BY GROUP A STREPTOCOCCI WITH SPECIAL REFERENCE TO ITS EFFECT ON THE TYPE-SPECIFIC M ANTIGEN. J Exp Med. 1945 Jun 1;81(6):573–592. doi: 10.1084/jem.81.6.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HECKLY R. J., GOLDWASSER E. Studies on infection with Bacillus anthracis; the production of an immunizing antigen in vitro. J Infect Dis. 1949 JanâFeb;84(1):92–97. doi: 10.1093/infdis/84.1.92. [DOI] [PubMed] [Google Scholar]