Abstract
A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. Twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were positive and 6 of 22 from apparently normal persons having Lansing-neutralizing antibody, while this held true for only 1 of 19 from those having no Lansing-neutralizing antibody. The fact that positive results were found in sera from patients having an infection with poliomyelitis virus of the Brunhilde type and at the same time no Lansing-neutralizing antibody brings up the possibility of the existence of a cross-reaction in complement fixation between the two types.
Full Text
The Full Text of this article is available as a PDF (794.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BODIAN D., MORGAN I. M., HOWE H. A. Differentiation of types of poliomyelitis viruses; the grouping of 14 strains into three basic immunological types. Am J Hyg. 1949 Mar;49(2):234–245. [PubMed] [Google Scholar]
- CASAIS J., ANSLOW R. O., SELZER G. Method for increasing the yield of complement-fixing antigens of certain neurotropic viruses, and the use of newborn mice for their production. J Lab Clin Med. 1951 Apr;37(4):663–664. [PubMed] [Google Scholar]
- CASALS J. Acetone-ether extracted antigens for complement-fixation with certain neurotropic viruses. Proc Soc Exp Biol Med. 1949 Feb;70(2):339–343. doi: 10.3181/00379727-70-16921. [DOI] [PubMed] [Google Scholar]
- CASALS J., OLITSKY P. K. A complement-fixation test for poliomyelitis virus. Proc Soc Exp Biol Med. 1950 Nov;75(2):315–318. doi: 10.3181/00379727-75-18184. [DOI] [PubMed] [Google Scholar]
- CASALS J., OLITSKY P. K., ANSLOW R. O. Adaptation of a Lansing strain of poliomyelitis virus to newborn mice. J Exp Med. 1951 Aug;94(2):111–121. doi: 10.1084/jem.94.2.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Casals J., Palacios R. DIAGNOSIS OF EPIDEMIC ENCEPHALITIS BY COMPLEMENT-FIXATION TEST. Science. 1941 Oct 3;94(2440):330–330. doi: 10.1126/science.94.2440.330. [DOI] [PubMed] [Google Scholar]
- OLITSKY P. K., CASALS J. The effect of incubation at 37C on the neutralization test with various encephalitis viruses including Lansing strains of poliomyelitis virus. J Immunol. 1948 Dec;60(4):487–496. [PubMed] [Google Scholar]
- STEIGMAN A. J., SABIN A. B. Antibody response of patients with poliomyelitis to virus recovered from their own alimentary tract. J Exp Med. 1949 Oct;90(4):349–372. doi: 10.1084/jem.90.4.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schlesinger R. W., Morgan I. M., Olitsky P. K. TRANSMISSION TO RODENTS OF LANSING TYPE POLIOMYELITIS VIRUS ORIGINATING IN THE MIDDLE EAST. Science. 1943 Nov 19;98(2551):452–454. doi: 10.1126/science.98.2551.452. [DOI] [PubMed] [Google Scholar]
- TURNER T. B., HOLLANDER D. H., BUCKLEY S., KOKKO U. P., WINSOR C. P. Age incidence and seasonal development of neutralizing antibodies to lansing poliomyelitis virus. Am J Hyg. 1950 Nov;52(3):323–347. doi: 10.1093/oxfordjournals.aje.a119427. [DOI] [PubMed] [Google Scholar]