Skip to main content
NCBI home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1951 Sep 1;94(3):191–211. doi: 10.1084/jem.94.3.191

MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)

Harold S Ginsberg 1
PMCID: PMC2136108  PMID: 14861378

Abstract

Infectious NDV particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. The lesions are indistinguishable from those of influenza A virus infection. This effect of NDV was blocked by intranasal injection of RDE or immune serum before virus inoculation, but not by immune serum injected 5 minutes or more after NDV. Influenza A virus infection did not diminish fixation of NDV in excised lungs but did interfere with the injurious action of this agent in the living mouse. The analogy between these reactions and those which take place in a progressive virus infection is pointed out, and the mechanism of production of lesions in virus pneumonias discussed.

Full Text

The Full Text of this article is available as a PDF (1.1 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURNET F. M. The haemolytic action of Newcastle disease virus. I. The two types of interaction between virus and red cell. Aust J Exp Biol Med Sci. 1950 May;28(3):299–309. doi: 10.1038/icb.1950.30. [DOI] [PubMed] [Google Scholar]
  2. Casals J. INFLUENCE OF AGE FACTORS ON SUSCEPTIBILITY OF MICE TO RABIES VIRUS. J Exp Med. 1940 Sep 30;72(4):445–451. doi: 10.1084/jem.72.4.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DALLDORF G., SICKLES G. M. A virus recovered from the feces of poliomyelitis patients pathogenic for suckling mice. J Exp Med. 1949 Jun 1;89(6):567–582. doi: 10.1084/jem.89.6.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Florman A. L. Some Alterations in Chicken Erythrocytes Which Follow Treatment with Influenza and Newcastle Disease Virus. J Bacteriol. 1948 Feb;55(2):183–196. doi: 10.1128/jb.55.2.183-196.1948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GINSBERG H. S., GOEBEL W. F., HORSFALL F. L., Jr The effect of polysaccharides on the reaction between erythrocytes and viruses, with particular reference to mumps virus. J Exp Med. 1948 May 1;87(5):411–424. doi: 10.1084/jem.87.5.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GINSBERG H. S., GOEBEL W. F., HORSFALL F. L., Jr The inhibitory effect of polysaccharide on mumps virus multiplication. J Exp Med. 1948 May 1;87(5):385–410. doi: 10.1084/jem.87.5.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GINSBERG H. S., HORSFALL F. L., Jr Concurrent infection with influenza virus and mumps virus or pneumonia virus of mice as bearing on the inhibition of virus multiplication by bacterial polysaccharides. J Exp Med. 1949 Jan;89(1):37–52. doi: 10.1084/jem.89.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HENLE W. Interference phenomena between animal viruses; a review. J Immunol. 1950 Mar;64(3):203–236. [PubMed] [Google Scholar]
  9. HORSFALL F. L., Jr, GINSBERG H. S. An improved CO2 cabinet for low temperature storage of infectious agents with gaseous CO2 excluded from the specimen compartment. J Bacteriol. 1951 Apr;61(4):443–451. doi: 10.1128/jb.61.4.443-451.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HORSFALL F. L., Jr, GINSBERG H. S. The dependence of the pathological lesion upon the multiplication of pneumonia virus of mice (PVM); kinetic relation between the degree of viral multiplication and the extent of pneumonia. J Exp Med. 1951 Feb;93(2):139–150. doi: 10.1084/jem.93.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Henle G., Henle W. STUDIES ON THE TOXICITY OF INFLUENZA VIRUSES : I. THE EFFECT OF INTRACEREBRAL INJECTION OF INFLUENZA VIRUSES. J Exp Med. 1946 Nov 30;84(6):623–637. doi: 10.1084/jem.84.6.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Henle W., Henle G. STUDIES ON THE TOXICITY OF INFLUENZA VIRUSES : II. THE EFFECT OF INTRA-ABDOMINAL AND INTRAVENOUS INJECTION OF INFLUENZA VIRUSES. J Exp Med. 1946 Nov 30;84(6):639–660. doi: 10.1084/jem.84.6.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hirst G. K. ADSORPTION OF INFLUENZA HEMAGGLUTININS AND VIRUS BY RED BLOOD CELLS. J Exp Med. 1942 Aug 1;76(2):195–209. doi: 10.1084/jem.76.2.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hirst G. K. STUDIES ON THE MECHANISM OF ADAPTATION OF INFLUENZA VIRUS TO MICE. J Exp Med. 1947 Oct 31;86(5):357–366. doi: 10.1084/jem.86.5.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Horsfall F. L., Hahn R. G. A LATENT VIRUS IN NORMAL MICE CAPABLE OF PRODUCING PNEUMONIA IN ITS NATURAL HOST. J Exp Med. 1940 Feb 29;71(3):391–408. doi: 10.1084/jem.71.3.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Horsfall F. L. NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUS : THE LINEAR RELATIONSHIP BETWEEN THE QUANTITY OF SERUM AND THE QUANTITY OF VIRUS NEUTRALIZED. J Exp Med. 1939 Jul 31;70(2):209–222. doi: 10.1084/jem.70.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. ISAACS A., EDNEY M. Interference between inactive and active influenza viruses in the chick embryo. II. The site of interference. Aust J Exp Biol Med Sci. 1950 Mar;28(2):231–238. doi: 10.1038/icb.1950.21. [DOI] [PubMed] [Google Scholar]
  18. LOOSLI C. G. The pathogenesis and pathology of experimental air-borne influenza virus A infections in mice. J Infect Dis. 1949 Mar–Apr;84(2):153–168. doi: 10.1093/infdis/84.2.153. [DOI] [PubMed] [Google Scholar]
  19. MELNICK J. L., GODMAN G. C. Pathogenesis of coxsackie virus infection; multiplication of virus and evolution of the muscle lesion in mice. J Exp Med. 1951 Mar;93(3):247–266. doi: 10.1084/jem.93.3.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Mellanby J. The Coagulation of blood: Part II. The actions of snake venoms, peptone and leech extract. J Physiol. 1909 Jul 2;38(6):441–503. doi: 10.1113/jphysiol.1909.sp001316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Nigg C. AN UNIDENTIFIED VIRUS WHICH PRODUCES PNEUMONIA AND SYSTEMIC INFECTION IN MICE. Science. 1942 Jan 9;95(2454):49–50. doi: 10.1126/science.95.2454.49-a. [DOI] [PubMed] [Google Scholar]
  22. Olitsky P. K., Sabin A. B., Cox H. R. AN ACQUIRED RESISTANCE OF GROWING ANIMALS TO CERTAIN NEUROTROPIC VIRUSES IN THE ABSENCE OF HUMORAL ANTIBODIES OR PREVIOUS EXPOSURE TO INFECTION. J Exp Med. 1936 Oct 31;64(5):723–737. doi: 10.1084/jem.64.5.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rake G., Jones H. P. STUDIES ON LYMPHOGRANULOMA VENEREUM : II. THE ASSOCIATION OF SPECIFIC TOXINS WITH AGENTS OF THE LYMPHOGRANULOMA-PSITTACOSIS GROUP. J Exp Med. 1944 May 1;79(5):463–486. doi: 10.1084/jem.79.5.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Rivers T. M., Haagen E., Muckenfuss R. S. A STUDY OF VACCINAL IMMUNITY IN TISSUE CULTURES. J Exp Med. 1929 Oct 31;50(5):673–685. doi: 10.1084/jem.50.5.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. SCHLESINGER R. W. Incomplete growth cycle of influenza virus in mouse brain. Proc Soc Exp Biol Med. 1950 Jul;74(3):541–548. doi: 10.3181/00379727-74-17966. [DOI] [PubMed] [Google Scholar]
  26. SUGG J. Y. The relation of the concentration of unadapted and adapted influenza virus in the mouse lung to the death or survival of the infected host. J Bacteriol. 1950 Oct;60(4):489–497. doi: 10.1128/jb.60.4.489-497.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sugg J. Y. AN INFLUENZA VIRUS PNEUMONIA OF MICE THAT IS NONTRANSFERABLE BY SERIAL PASSAGE. J Bacteriol. 1949 Apr;57(4):399–403. doi: 10.1128/jb.57.4.399-403.1949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Taylor R. M. EXPERIMENTAL INFECTION WITH INFLUENZA A VIRUS IN MICE : THE INCREASE IN INTRAPULMONARY VIRUS AFTER INOCULATION AND THE INFLUENCE OF VARIOUS FACTORS THEREON. J Exp Med. 1941 Jan 1;73(1):43–55. doi: 10.1084/jem.73.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES