Abstract
The intradermal injection of ovalbumin in rabbits sensitized to this antigen, under circumstances resulting in the elicitation of the Arthus phenomenon, causes a systemic reaction involving alterations in leucocytes and platelets, and results in cellular thrombosis of capillaries and veins in the injected skin areas. An abnormal metabolic process develops in the injected skin areas and may be the cause of the vulnerability of these vessels to leucocyte-platelet thrombosis. The form of vascular damage determining the Arthus phenomenon is similar to that already observed in the case of the Shwartzman phenomenon, and the results of various metabolic, hematologic, and histologic studies indicate that the mechanisms resulting in both phenomena are closely related.
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Selected References
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- BECKER R. M. Suppression of local tissue reactivity, Shwartzman phenomenon, by nitrogen mustard, benzol, and X-ray irradiation. Proc Soc Exp Biol Med. 1948 Nov;69(2):247–250. doi: 10.3181/00379727-69-16680. [DOI] [PubMed] [Google Scholar]
- BLACK-SCHAFFER B., MILAM J. W., BROCKMAN D. D., COONRAD E. V., SILVERMAN S. B. Production of the shwartzman phenomenon by a single injection technic. J Exp Med. 1950 May 1;91(5):539–548. doi: 10.1084/jem.91.5.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAMMIN G. J., BUKANTZ S. C. Modification of biologic response in experimental hypersensitivity. J Am Med Assoc. 1949 Feb 5;139(6):358–362. doi: 10.1001/jama.1949.02900230012004. [DOI] [PubMed] [Google Scholar]
- Howell W. H., Donahue D. D. THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS. J Exp Med. 1937 Jan 31;65(2):177–203. doi: 10.1084/jem.65.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LUTZ B. R. Intravascular agglutination of the formed elements of blood. Physiol Rev. 1951 Apr;31(2):107–130. doi: 10.1152/physrev.1951.31.2.107. [DOI] [PubMed] [Google Scholar]
- STETSON C. A., Jr Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis. J Exp Med. 1951 May;93(5):489–504. doi: 10.1084/jem.93.5.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THOMAS L., STETSON C. A. Studies on the mechanism of the Shwartzman phenomenon. J Exp Med. 1949 May;89(5):461–478. doi: 10.1084/jem.89.5.461. [DOI] [PMC free article] [PubMed] [Google Scholar]