Abstract
All analysis of the mechanisms involved in the pathogenesis of the visceral lesions produced by Shiga toxin in the dog has indicated that the structural changes are produced by a vascular mechanism which is under control of the sympathetic nervous system. Paralysis of the latter at the myoneural junction or in the ganglia by means of drugs served to prevent the tissue changes as well as the hyperglycemia and hemoconcentration characteristic of the sympathomimetic response. The observations indicated that the toxin acted via a mechanism located in the central nervous system. Further studies of the action of Shiga toxin by means of cerebral cross-circulation are reported here. In these the cerebral blood flow of one dog derived from the circulation of the trunk and limbs of another. Injection of the toxin into the femoral vein of this latter dog resulted in the appearance of visceral lesions, hemoconcentration, and hyperglycemia in the former whose brain only received blood containing the toxin. The resulting visceral changes were identical with those observed in the intact unanesthetized dog which had received the toxin directly. The observations indicate that, in dogs, Shiga toxin produces its characteristic visceral lesions via the central nervous system. Possible mechanisms are discussed.
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Selected References
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- Jackson J. H. The Croonian Lectures on Evolution and Dissolution of the Nervous System. Br Med J. 1884 Apr 5;1(1214):660–663. doi: 10.1136/bmj.1.1214.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PENNER A. The pathogenesis of experimental dysentery intoxication: further studies in the inhibition of the lesions. Gastroenterology. 1951 Dec;19(4):855–863. [PubMed] [Google Scholar]
- Penner A., Bernheim A. I. EXPERIMENTAL PRODUCTION OF DIGESTIVE TRACT ULCERATIONS. J Exp Med. 1939 Oct 31;70(5):453–460. doi: 10.1084/jem.70.5.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Penner A., Bernheim A. I. STUDIES IN THE PATHOGENESIS OF EXPERIMENTAL DYSENTERY INTOXICATION. J Exp Med. 1942 Sep 1;76(3):271–282. doi: 10.1084/jem.76.3.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- YOUNG L. E., O'BRIEN W. A., MILLER G., SWISHER S. N., ERVIN D. M., CHRISTIAN R. M., YUILE C. L. Erythrocyte-isoantibody reactions in dogs. Trans N Y Acad Sci. 1951 Apr;13(6):209–213. doi: 10.1111/j.2164-0947.1951.tb00041.x. [DOI] [PubMed] [Google Scholar]