Abstract
CF tests with Type 2 poliomyelitis antigen (MEF1) were performed on the pre- and postinfection sera of 20 cynomolgus monkeys which developed paralytic, non-paralytic, or inapparent infection following oral administration of a Type 2 strain of virus (Y-SK). All the monkeys developed neutralizing antibody, and 17 developed CF antibody in an original serum dilution titer of 1:4 or greater. The 3 monkeys which did not develop this level of CF antibody were in a group of 7 which died within 8 days after onset of paralysis. The CF titers were as high at 2 to 6 days after onset of paralysis in the other 4 moribund or dead monkeys as in the surviving animals tested 4 weeks after the first dose of virus and the CF titers were of the same order of magnitude in the groups with paralytic, non-paralytic, or inapparent infection. The Type 2 poliomyelitis CF titers developed in monkeys as a result of infection with homotypic virus were not greater than those found in human beings infected with heterotypic Type 1 poliomyelitis strains.
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Selected References
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- CASALS J., OLITSKY P. K., ANSLOW R. O. A specific complement-fixation test for infection with poliomyelitis virus. J Exp Med. 1951 Aug;94(2):123–137. doi: 10.1084/jem.94.2.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CASALS J., OLITSKY P. K., SABIN A. B. Development, persistence, and significance of type 2, poliomyelitis complement-fixing antibody in man. J Exp Med. 1952 Jul;96(1):35–53. doi: 10.1084/jem.96.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAMMON W. M., ROBERTS E. C. Serum neutralizing antibodies to the infecting strain of virus in poliomyelitis patients. Proc Soc Exp Biol Med. 1948 Nov;69(2):256–258. doi: 10.3181/00379727-69-16682. [DOI] [PubMed] [Google Scholar]
- STEIGMAN A. J., SABIN A. B. Antibody response of patients with poliomyelitis to virus recovered from their own alimentary tract. J Exp Med. 1949 Oct;90(4):349–372. doi: 10.1084/jem.90.4.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sabin A. B., Ward R. NATURE OF NON-PARALYTIC AND TRANSITORY PARALYTIC POLIOMYELITIS IN RHESUS MONKEYS INOCULATED WITH HUMAN VIRUS. J Exp Med. 1941 May 31;73(6):757–770. doi: 10.1084/jem.73.6.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VON MAGNUS H., MELNICK J. L. Antibody response in monkeys following oral administration of poliomyelitis virus. J Immunol. 1948 Dec;60(4):583–596. [PubMed] [Google Scholar]