Abstract
The intracellular distribution of herpes virus in embryonic liver was investigated. 80 per cent of the virus was found in the cytoplasm in what appears to be a form uncombined with mitochondria or nuclei. A significant amount of the virus (16 per cent) was found bound to the mitochondria by an intimate attachment. Furthermore evidence was obtained that the mitochondria from liver tissue undergo a selective deterioration when infected with herpes virus. The concept is advanced that these organelles function in the development of virus.
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Selected References
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- ACKERMANN W. W., FRANCIS T., Jr Some biochemical aspects of herpes infection. Proc Soc Exp Biol Med. 1950 May;74(1):123–126. doi: 10.3181/00379727-74-17829. [DOI] [PubMed] [Google Scholar]
- ACKERMANN W. W., KLERNSCHMIDT E. Concerning the relation of the Krebs cycle to virus propagation. J Biol Chem. 1951 Mar;189(1):421–428. [PubMed] [Google Scholar]
- ACKERMANN W. W. The relation of the Krebs cycle to viral synthesis. II. The effect of sodium fluoroacetate on the propagation of influenza virus in mice. J Exp Med. 1951 Jun;93(6):635–642. doi: 10.1084/jem.93.6.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BANG F. B. Cellular changes in the chick chorio-allantoic membrane infected with herpes simplex and vaccinia; a study with thin sections for the electron microscope. Bull Johns Hopkins Hosp. 1950 Dec;87(6):511–547. [PubMed] [Google Scholar]
- FRANCIS T., Jr, KURTZ H. B. The relation of herpes virus to the cell nucleus. Yale J Biol Med. 1950 Jul;22(6):579–587. [PMC free article] [PubMed] [Google Scholar]
- HOGEBOOM G. H., SCHNEIDER W. C. Cytochemical studies of mammalian tissues. III. Isocitric dehydrogenase and triphosphopyridine nucleotide-cytochrome c reductase of mouse liver. J Biol Chem. 1950 Oct;186(2):417–427. [PubMed] [Google Scholar]