Abstract
A procedure has been described for the centrifugal fractionation of the cellular particulate components of CNS tissue infected with poliomyelitis virus. A study of the distribution of infectivity among these components revealed that approximately four-fifths of the virus is found free in the submicroscopic particle fraction. The validity of the conclusion that the virus is located in this fraction of the intact neuron is discussed.
Full Text
The Full Text of this article is available as a PDF (894.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- SCHNEIDER W. C., HOGEBOOM G. H. Cytochemical studies of mammalian tissues; the isolation of cell components by differential centrifugation: a review. Cancer Res. 1951 Jan;11(1):1–22. [PubMed] [Google Scholar]
- SCHWERDT C. E., MERRELL M. Precision of measurement of Lansing virus infectivity in cotton rats. Am J Hyg. 1952 Mar;55(2):268–275. doi: 10.1093/oxfordjournals.aje.a119520. [DOI] [PubMed] [Google Scholar]