Abstract
Collagen fibers have been formed in vitro by the action of heparm on solutions of collagen. Heparin was found to be effective in inducing collagen fiber formation when present in concentrations as low as 1–80,000. It is postulated that mast cells, by virtue of the heparin which they produce, may play a role in the formation of collagen.
Full Text
The Full Text of this article is available as a PDF (629.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BENSLEY S. H. Histological studies of the reactions of cells and intercellular substances of loose connective tissue to the spreading factor of testicular extracts. Ann N Y Acad Sci. 1950 May 31;52(7):983–988. doi: 10.1111/j.1749-6632.1950.tb53993.x. [DOI] [PubMed] [Google Scholar]
- EHRICH W. E. Nature of collagen diseases. Am Heart J. 1952 Jan;43(1):121–156. doi: 10.1016/0002-8703(52)90034-3. [DOI] [PubMed] [Google Scholar]
- GERSH I., CATCHPOLE H. R. The organization of ground substance and basement membrane and its significance in tissue injury disease and growth. Am J Anat. 1949 Nov;85(3):457-521, incl 7 pl. doi: 10.1002/aja.1000850304. [DOI] [PubMed] [Google Scholar]
- HIGHBERGER J. H., GROSS J., SCHMITT F. O. The interaction of mucoprotein with soluble collagen; an electron microscope study. Proc Natl Acad Sci U S A. 1951 May;37(5):286–291. doi: 10.1073/pnas.37.5.286. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KLEMPERER P. The concept of collagen diseases. Am J Pathol. 1950 Jul;26(4):505–519. [PMC free article] [PubMed] [Google Scholar]
- MEYER K., RAPPORT M. M. The mucopolysaccharides of the ground substance of connective tissue. Science. 1951 May 25;113(2943):596–599. doi: 10.1126/science.113.2943.596. [DOI] [PubMed] [Google Scholar]
- McCLEERY R. S., SCHAFFARZICK W. R., LIGHT R. A. An experimental study of the effect of heparin on the local pathology of burns. Surgery. 1949 Sep;26(3):548–564. [PubMed] [Google Scholar]
- Oliver J., Bloom F., Mangieri C. ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS. J Exp Med. 1947 Jul 31;86(2):107–116. doi: 10.1084/jem.86.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VANAMEE P., PORTER K. R. Observations with the electron microscope on the solvation and reconstitution of collagen. J Exp Med. 1951 Sep;94(3):255–266. doi: 10.1084/jem.94.3.255. [DOI] [PMC free article] [PubMed] [Google Scholar]