Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1952 Sep 30;96(4):313–318. doi: 10.1084/jem.96.4.313

THE HALF-LIFE OF HOMOLOGOUS GAMMA GLOBULIN (ANTIBODY) IN SEVERAL SPECIES

Frank J Dixon 1, David W Talmage 1, Paul H Maurer 1, Maria Deichmiller 1
PMCID: PMC2136155  PMID: 12981216

Abstract

1. The half-lives of homologous gamma globulins labelled with I131 agree well with the half-lives of passively administered homologous antibodies and provide a simple, quantitative tool for the determination of antibody half-life when immunochemical techniques are difficult to apply. 2. The half-lives of gamma globulin or antibody vary markedly from species to species and apparently even among age groups within a species. 3. The half-lives of gamma globulin or antibody seem to be dependent, at least in part, on the metabolic rate of the host.

Full Text

The Full Text of this article is available as a PDF (288.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARR M., GLENNY A. T., RANDALL K. J. Concentration of diphtheria antitoxin in cord blood and rate of loss in babies. Lancet. 1949 Aug 20;2(6573):324–326. doi: 10.1016/s0140-6736(49)90047-1. [DOI] [PubMed] [Google Scholar]
  2. GERMUTH F. G., Jr, OYAMA J., OTTINGER B. The mechanism of action of 17-hydroxy-11-dehydrocorticosterone (compound E) and of the adrenocorticotropic hormone in experimental hypersensitivity in rabbits. J Exp Med. 1951 Aug;94(2):139–170. doi: 10.1084/jem.94.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heidelberger M., Kendall F. E. A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : III. THE REACTION BETWEEN CRYSTALLINE EGG ALBUMIN AND ITS HOMOLOGOUS ANTIBODY. J Exp Med. 1935 Oct 31;62(5):697–720. doi: 10.1084/jem.62.5.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. STERNBERGER L. A., PETERMANN M. L. The effect of the calcium hydroxide-calcium aluminate antibody purification procedure on the physical properties of rabbit gamma globulin. J Immunol. 1951 Sep;67(3):207–212. [PubMed] [Google Scholar]
  5. TALIAFERRO W. H., TALIAFERRO L. G. The dynamics of hemolysin formation in intact and splenectomized rabbits. J Infect Dis. 1950 Jul-Aug;87(1):37–62. doi: 10.1093/infdis/87.1.37. [DOI] [PubMed] [Google Scholar]
  6. TALMAGE D. W., DIXON F. J., BUKANTZ S. C., DAMMIN G. J. Antigen elimination from the blood as an early manifestation of the immune response. J Immunol. 1951 Oct;67(4):243–255. [PubMed] [Google Scholar]
  7. WIENER A. S. The half-life of passively acquired antibody globulin molecules in infants. J Exp Med. 1951 Sep;94(3):213–221. doi: 10.1084/jem.94.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES