Abstract
Poliomyelitis virus, when ingested by cynomolgus monkeys in their regular food, infected peripheral ganglia (nodose) as early as the 3rd day, as shown by recovery of the virus. Conditions on the 2nd and 4th days were not investigated, but on the 5th and 6th days, virus was recovered from the Gasserian and nodose ganglia, and from the superior cervical sympathetic and celiac ganglia. The findings indicate that the method of oropharyngeal swabbing used in a study already reported and the method of simple feeding used in the present study produce comparable results. Viremia, noted in the present study, was contemporaneous with virus recoveries from the ganglia. Reasons are presented why the peripheral ganglia are the most probable source of viremia since these are the only known site of early lesions (which are typical and appear as early as the 2nd day after oral infection) and no lesions are known to occur in extraneural tissues. Invasion of the CNS occurred in 3 animals out of 11; one on the 5th and 2 on the 6th day. Whether this was due to viremia or to centripetal extension along axonal channels is not clear.
Full Text
The Full Text of this article is available as a PDF (416.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BODIAN D. A reconsideration of the pathogenesis of poliomyelitis. Am J Hyg. 1952 May;55(3):414–438. doi: 10.1093/oxfordjournals.aje.a119533. [DOI] [PubMed] [Google Scholar]
- BODIAN D. Histopathologic basis of clinical findings in poliomyelitis. Am J Med. 1949 May;6(5):563–578. doi: 10.1016/0002-9343(49)90130-8. [DOI] [PubMed] [Google Scholar]
- Enders J. F., Weller T. H., Robbins F. C. Cultivation of the Lansing Strain of Poliomyelitis Virus in Cultures of Various Human Embryonic Tissues. Science. 1949 Jan 28;109(2822):85–87. doi: 10.1126/science.109.2822.85. [DOI] [PubMed] [Google Scholar]
- FABER H. K., SILVERBERG R. J., LUZ L. A., DONG L. Studies on entry and egress of poliomyelitis infection. III. Excretion of the virus during the presymptomatic period in parenterally inoculated monkeys. J Exp Med. 1950 Dec;92(6):571–589. doi: 10.1084/jem.92.6.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FABER H. K. The question of extraneural growth in vivo of poliomyelitis virus. Science. 1951 Nov 30;114(2970):570–571. doi: 10.1126/science.114.2970.570. [DOI] [PubMed] [Google Scholar]
- HORSTMANN D. M. Poliomyelitis virus in blood of orally infected monkeys and chimpanzees. Proc Soc Exp Biol Med. 1952 Mar;79(3):417–419. doi: 10.3181/00379727-79-19398. [DOI] [PubMed] [Google Scholar]
- HOWE H. A., BODIAN D., MORGAN I. M. Subclinical poliomyelitis in the chimpanzee and its relation to alimentary reinfection. Am J Hyg. 1950 Jan;51(1):85-108, tab. doi: 10.1093/oxfordjournals.aje.a119379. [DOI] [PubMed] [Google Scholar]
- PAUL J. R. Current knowledge and trends in poliomyelitis. Merck Rep. 1952 Jan;61(1):3–8. [PubMed] [Google Scholar]
- ROBBINS F. C., ENDERS J. F., WELLER T. H. Cytopathogenic effect of poliomyelitis viruses in vitro on, human embryonic tissues. Proc Soc Exp Biol Med. 1950 Nov;75(2):370–374. doi: 10.3181/00379727-75-18202. [DOI] [PubMed] [Google Scholar]
- Sabin A. B., Ward R. THE NATURAL HISTORY OF HUMAN POLIOMYELITIS : I. DISTRIBUTION OF VIRUS IN NERVOUS AND NON-NERVOUS TISSUES. J Exp Med. 1941 May 31;73(6):771–793. doi: 10.1084/jem.73.6.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WENNER H. A., RABE E. F. The recovery of virus from regional lymph nodes of fatal human cases of poliomyelitis. Am J Med Sci. 1951 Sep;222(3):292–299. doi: 10.1097/00000441-195109000-00007. [DOI] [PubMed] [Google Scholar]