Abstract
A final concentration of 3 x 10–5 M spermine or spermidine inhibited the growth of mammalian tubercle bacilli in a modified Dubos liquid medium. Various related amino compounds, including isolated portions of the spermine molecule and the products of its chemical degradation, did not manifest similar antimycobacterial activity.
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Selected References
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- HIRSCH J. G., DUBOS R. J. The effect of spermine on tubercle bacilli. J Exp Med. 1952 Feb;95(2):191–208. doi: 10.1084/jem.95.2.191. [DOI] [PMC free article] [PubMed] [Google Scholar]