Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1953 Jul 1;98(1):21–34. doi: 10.1084/jem.98.1.21

MORPHOLOGIC VARIATION IN PNEUMOCOCCUS

I. AN ANALYSIS OF THE BASES FOR MORPHOLOGIC VARIATION IN PNEUMOCOCCUS AND DESCRIPTION OF A HITHERTO UNDEFINED MORPHOLOGIC VARIANT

Robert Austrian 1
PMCID: PMC2136274  PMID: 13069647

Abstract

The problem of morphologic variation in pneumococcus has been reviewed and the desirability of studying such variation through an examination of bacterial cells rather than of bacterial colonies has been pointed out. To further this objective, a new terminology to describe the morphologic variants of pneumococcus, potentially applicable to other bacterial species, has been proposed. A hitherto undefined morphologic variant of pneumococcus, the filamentous capsulated (fil+ S+) variant, has been defined and its relationship to the three previously recognized non-filamentous capsulated (fil- S+), nonfilamentous non-capsulated (fil- S-), and filamentous non-capsulated (fil+ S-) variants has been presented.

Full Text

The Full Text of this article is available as a PDF (1.1 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUSTRIAN R., MacLEOD C. M. A type-specific protein from pneumococcus. J Exp Med. 1949 Apr 1;89(4):439–450. doi: 10.1084/jem.89.4.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. AUSTRIAN R., MacLEOD C. M. Acquisition of M. protein by pneumococci through transformation reactions. J Exp Med. 1949 Apr 1;89(4):451–460. doi: 10.1084/jem.89.4.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Avery O. T., Macleod C. M., McCarty M. STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES : INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III. J Exp Med. 1944 Feb 1;79(2):137–158. doi: 10.1084/jem.79.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Macleod C. M., Krauss M. R. STEPWISE INTRATYPE TRANSFORMATION OF PNEUMOCOCCUS FROM R TO S BY WAY OF A VARIANT INTERMEDIATE IN CAPSULAR POLYSACCHARIDE PRODUCTION. J Exp Med. 1947 Nov 30;86(6):439–452. doi: 10.1084/jem.86.6.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. POMALES-LEBRON A., MORALES-OTERO P. Dissociation among Lancefield's group B streptococci of human and bovine origin. Proc Soc Exp Biol Med. 1949 Apr;70(4):612–616. doi: 10.3181/00379727-70-17012. [DOI] [PubMed] [Google Scholar]
  6. Reed G. B. Independent Variation of Several Characteristics in S. marcescens. J Bacteriol. 1937 Sep;34(3):255–266. doi: 10.1128/jb.34.3.255-266.1937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. SHANKAR K., BARD R. C. The effect of metallic ions on the growth and morphology of Clostridium perfringens. J Bacteriol. 1952 Feb;63(2):279–290. doi: 10.1128/jb.63.2.279-290.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. TAYLOR H. E. Additive effects of certain transforming agents from some variants of pneumococcus. J Exp Med. 1949 Apr 1;89(4):399–424. doi: 10.1084/jem.89.4.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. WEBB M. The influence of magnesium on cell division. V. The effect of magnesium on the growth of bacteria in chemically-defined media of varying complexity. J Gen Microbiol. 1951 Aug;5(3):485–495. doi: 10.1099/00221287-5-3-485. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES